Bismuth Subsalicylate and Omadacycline Interaction
Drug interaction information between Bismuth Subsalicylate and Omadacycline.
Bismuth Subsalicylate and Omadacycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bismuth Subsalicylate and Omadacycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bismuth subsalicylate interferes with how your body takes in the antibiotic, making the medicine less effective at fighting infection.
FDA Label Information
( 7.1 ) Absorption of tetracyclines, including NUZYRA, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron containing preparations. 7.2 Antacids and Iron Preparations Absorption of oral tetracyclines, including NUZYRA, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron containing preparations [see Dosage and Administration (2.1) ].
Bismuth Subsalicylate Also Interacts With
- Doxycycline minor
- Doxycycline Hyclate minor
Frequently Asked Questions
What SPL severity band is on file for Bismuth Subsalicylate + Omadacycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bismuth Subsalicylate has 3 labeled pairs on file vs Omadacycline's 1. In the minor band specifically: Bismuth Subsalicylate has 3 (also Doxycycline, Doxycycline Hyclate); Omadacycline has 1.
What mechanism field is on file for Bismuth Subsalicylate and Omadacycline?
Bismuth subsalicylate interferes with how your body takes in the antibiotic, making the medicine less effective at fighting infection.
Bismuth Subsalicylate's labeled portfolio outnumbers Omadacycline
SPL source-record counts only. This page's band is minor · classes on file: Bismuth Subsalicylate (Antidiarrheal / Antacid); Omadacycline (Tetracycline Antibiotic).
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Bismuth Subsalicylate
- Doxycycline
- Doxycycline Hyclate
0 major · 0 moderate · 1 minor · 1 total
Omadacycline has no other minor-band peer in this dataset besides Bismuth Subsalicylate.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.