Prescription medication · Anti-TSLP Monoclonal Antibody

tezepelumab

Also sold as Tezspire. Tezspire is used to treat severe asthma in adults and children 12 years and older.

Data updated 2026-05-15

Rx
Availability

tezepelumab (Tezspire) is a prescription Anti-TSLP Monoclonal Antibody. Tezspire is used to treat severe asthma in adults and children 12 years and older.

Tezspire is a medicine that can help control severe asthma and chronic rhinosinusitis with nasal polyps. It works by blocking a substance in your body that causes inflammation.

Verify with FDA → · CMS NADAC pricing →

Compare with Another Drug →

What it does

Tezspire is used to treat severe asthma in adults and children 12 years and older.

Common side effects

Sore throat, Joint pain, Back pain

Key warnings

If you have a parasitic infection, it should be treated before you start using Tezspire.

The sections below are summarized in plain English from tezepelumab's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Tezspire is a special type of antibody that blocks a protein called TSLP. TSLP causes inflammation in the airways and sinuses. By blocking TSLP, Tezspire helps to reduce swelling and mucus production.

Serious Warnings

If you have a parasitic infection, it should be treated before you start using Tezspire. Avoid live vaccines while using Tezspire. Do not stop taking steroid medicines suddenly when you start Tezspire. Talk to your doctor about how to slowly lower your steroid dose if needed.

Common Questions

What should I tell my doctor before using Tezspire?
Tell your doctor if you are allergic to Tezspire or any of its ingredients. Also, tell them if you have any other medical conditions, especially a parasitic infection.
Can Tezspire be used for sudden asthma attacks?
No, Tezspire is not a rescue medicine. It will not help with sudden asthma symptoms. Use your rescue inhaler for asthma attacks.
How long does it take for Tezspire to start working?
It may take several weeks for Tezspire to start working. Continue to take your other asthma medicines as prescribed by your doctor.
What are the symptoms of a hypersensitivity reaction?
Symptoms can include rash, itching, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing.
Can I get vaccinated while using Tezspire?
Avoid live vaccines while using Tezspire. Talk to your doctor before getting any vaccines.
What if I still have asthma symptoms after starting Tezspire?
Contact your doctor if your asthma symptoms do not improve or get worse after starting Tezspire.
How is Tezspire given?
Tezspire is given as an injection under the skin (subcutaneous injection).
Can I inject Tezspire myself?
Yes, you can inject Tezspire yourself if you have been properly trained by a healthcare provider.
What should I do if I accidentally inject too much Tezspire?
Contact your doctor or go to the nearest emergency room.
How often do I need to get Tezspire injections?
Tezspire is given once every 4 weeks.
What are the common side effects of tezepelumab?
The registry lists Sore throat, Joint pain, Back pain, Runny nose, Upper respiratory infection among the most-reported FAERS reaction terms for tezepelumab. These counts are not an individual symptom assessment.
What drug class is tezepelumab?
tezepelumab belongs to the Anti-TSLP Monoclonal Antibody drug class. It requires a prescription (Rx). Tezspire is used to treat severe asthma in adults and children 12 years and older.
What pregnancy or breastfeeding source fields are listed for tezepelumab?
The FDA label for tezepelumab contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in Anti-TSLP Monoclonal Antibody

Other drugs grouped near tezepelumab - same-class peers and common alternatives.

aclidinium

Tudorza Pressair

Compare with tezepelumab →

albuterol

Ventolin, ProAir

Albuterol is a drug that helps you breathe easier.

Compare with tezepelumab →

albuterol/ipratropium

Combivent Respimat, DuoNeb

Combivent Respimat is a combination medicine that helps open your airways.

Compare with tezepelumab →

beclomethasone

Qvar

Qvar Redihaler is an inhaled medicine that helps control asthma symptoms.

Compare with tezepelumab →

benralizumab

Fasenra

Fasenra is a medicine that can help treat severe asthma and EGPA.

Compare with tezepelumab →

Compare tezepelumab vs aclidinium side-by-side →

Medication Guides

Understanding Drug Interactions

How CYP450 enzymes, inhibitors, and inducers affect your medications

Generic vs Brand Name Drugs

FDA requirements, cost savings, and when the difference matters

Narrow Therapeutic Index Drugs

FDA bioequivalence and label-record context for narrow therapeutic index medicines

Common Drug Interactions

Dangerous medication combinations and how to protect yourself

Save on tezepelumab

Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.

Check Prices on GoodRx →

Disclosure: This link may earn us a commission at no extra cost to you. See our terms.

What the FDA Data Shows for tezepelumab

The FDA label for tezepelumab (sold under brand names such as Tezspire) classifies it as a prescription-only medication in the Anti-TSLP Monoclonal Antibody class. Tezspire is used to treat severe asthma in adults and children 12 years and older. Official labeling lists 8 commonly reported side effects, including Sore throat, Joint pain, Back pain.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. Interaction data is drawn directly from FDA-approved prescribing information. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: October 17, 2025

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page