tezepelumab
Brand names: Tezspire
Tezspire is a medicine that can help control severe asthma and chronic rhinosinusitis with nasal polyps. It works by blocking a substance in your body that causes inflammation.
What it does
Tezspire is used to treat severe asthma in adults and children 12 years and older.
Common side effects
Sore throat, Joint pain, Back pain
Key warnings
If you have a parasitic infection, it should be treated before you start using Tezspire.
How It Works
Tezspire is a special type of antibody that blocks a protein called TSLP. TSLP causes inflammation in the airways and sinuses. By blocking TSLP, Tezspire helps to reduce swelling and mucus production.
How to Take It
You will receive Tezspire as an injection under the skin every 4 weeks. The recommended dose is 210 mg. A healthcare provider will usually give you the injection. You or your caregiver can also give the injection if you are properly trained.
Pregnancy & Breastfeeding
It is not known if Tezspire will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Tezspire passes into breast milk. Talk to your doctor about the best way to feed your baby if you are using Tezspire.
Missed Dose
If you miss a dose of Tezspire, take it as soon as you remember. Then, continue with your regular schedule. If it is almost time for your next dose, just take that dose as planned.
Storage
Store Tezspire in the refrigerator between 36°F to 46°F (2°C to 8°C) in its original carton to protect from light. If needed, Tezspire may be stored at room temperature for up to 30 days.
Serious Warnings
If you have a parasitic infection, it should be treated before you start using Tezspire. Avoid live vaccines while using Tezspire. Do not stop taking steroid medicines suddenly when you start Tezspire. Talk to your doctor about how to slowly lower your steroid dose if needed.
Common Questions
What should I tell my doctor before using Tezspire?
Can Tezspire be used for sudden asthma attacks?
How long does it take for Tezspire to start working?
What are the symptoms of a hypersensitivity reaction?
Can I get vaccinated while using Tezspire?
What if I still have asthma symptoms after starting Tezspire?
How is Tezspire given?
Can I inject Tezspire myself?
What should I do if I accidentally inject too much Tezspire?
How often do I need to get Tezspire injections?
What are the common side effects of tezepelumab?
What drug class is tezepelumab?
Is tezepelumab safe during pregnancy?
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What the FDA Data Shows for tezepelumab
The FDA label for tezepelumab (sold under brand names such as Tezspire) classifies it as a prescription-only medication in the Anti-TSLP Monoclonal Antibody class. Tezspire is used to treat severe asthma in adults and children 12 years and older. Official labeling lists 8 commonly reported side effects, including Sore throat, Joint pain, Back pain.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. Interaction data is drawn directly from FDA-approved prescribing information. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: October 17, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages