ciclesonide nasal

In a drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged.

Mechanism: Ketoconazole slows down the process of clearing the active medicine from your system. This results in much higher levels of the drug in your body.

What to do: Use this combination with caution. Your healthcare provider may need to check for signs of increased steroid exposure.

Erythromycin, a moderate inhibitor of cytochrome P450 3A4, had no effect on the pharmacokinetics of either des-ciclesonide or erythromycin following oral inhalation of ciclesonide [see Clinical Pharmacology ( 12.3 )] .

Mechanism: Studies show that erythromycin does not change the amount of medicine that stays in your body.

What to do: No dosage adjustments are necessary when using these two medications together.

7 DRUG INTERACTIONS In vitro studies and clinical pharmacology studies suggested that des-ciclesonide has no potential for metabolic drug interactions or protein binding-based drug interactions [see Clinical Pharmacology ( 12.3 )] . In a drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged. Erythromycin, a moderate inhibitor of cytochrome P450 3A4, had no effect on the ph...

Mechanism: This drug does not seem to change how other medicines are broken down or carried in the blood.

What to do: You generally do not need to worry about this drug causing interactions with other medications.