ixekizumab
Brand names: Taltz
Taltz is a medicine that can help treat plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. It works by blocking a protein that causes inflammation.
Drug Pricing (NADAC)
Brand Price
$6681.55/unit
Generic Available
No
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Taltz is used to treat plaque psoriasis in adults and children 6 years and older.
Common side effects
Injection site reactions (pain, redness, swelling), Upper respiratory tract infections (like a cold), Nausea
Key warnings
Taltz can increase your risk of getting a serious infection.
How It Works
Taltz is a type of medicine called an interleukin-17A antagonist. It works by blocking a protein called IL-17A in your body. This protein causes inflammation, which leads to the symptoms of psoriasis and arthritis.
How to Take It
Taltz is given as a shot under the skin (subcutaneous injection). For adults with plaque psoriasis, psoriatic arthritis or ankylosing spondylitis, the starting dose is 160 mg (two 80 mg shots) at Week 0. After that, you will get 80 mg every 4 weeks. For non-radiographic axial spondyloarthritis, the dose is 80 mg every 4 weeks.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Taltz will harm your unborn baby. There is a pregnancy registry for women who use Taltz during pregnancy; you can enroll by calling 1-800-284-1695. Talk to your doctor if you are breastfeeding or plan to breastfeed. It is not known if Taltz passes into breast milk.
Missed Dose
If you miss a dose of Taltz, inject it as soon as you remember. Then, take your next dose at your regular scheduled time.
Storage
Store Taltz in the refrigerator between 36°F and 46°F (2°C to 8°C).
Side Effects (from patient reports)
Based on 19,574 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 35,897 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2016–2025.
Total Reports
35,897
Death-Related Reports
529
Hospitalization Reports
2,822
Top Indication
Psoriasis
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | INJECTION SITE PAIN | 3,851 |
| 2 | DRUG INEFFECTIVE | 3,177 |
| 3 | PSORIASIS | 3,159 |
| 4 | INJECTION SITE ERYTHEMA | 2,168 |
| 5 | INJECTION SITE REACTION | 1,749 |
| 6 | INJECTION SITE SWELLING | 1,626 |
| 7 | INCORRECT DOSE ADMINISTERED | 1,120 |
| 8 | PRODUCT DOSE OMISSION ISSUE | 931 |
| 9 | COVID-19 | 918 |
| 10 | PAIN | 875 |
| 11 | ARTHRALGIA | 862 |
| 12 | THERAPY INTERRUPTED | 815 |
| 13 | DIARRHOEA | 808 |
| 14 | RASH | 793 |
| 15 | INJECTION SITE PRURITUS | 782 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Taltz can increase your risk of getting a serious infection. Before starting Taltz, your doctor should check you for tuberculosis (TB). Avoid live vaccines while taking Taltz. If you have a serious allergic reaction, stop using Taltz right away.
Common Questions
What should I do if I have an infection while taking Taltz?
Can I get vaccines while taking Taltz?
How long does it take for Taltz to start working?
Can Taltz cure my condition?
Are there any foods or drinks I should avoid while taking Taltz?
Can I take other medicines with Taltz?
What if I have inflammatory bowel disease?
How is Taltz supplied?
What do I do with used needles and syringes?
What if Taltz has been left at room temperature?
What are the common side effects of ixekizumab?
What drug class is ixekizumab?
Is ixekizumab safe during pregnancy?
Related Medications in Anti-IL-17A Monoclonal Antibody
Other drugs grouped near ixekizumab — same-class peers and common alternatives.
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apremilast
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azelaic acid
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benzoyl peroxide
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betamethasone
Diprosone, Luxiq
Betamethasone dipropionate cream is a strong steroid medicine used on the skin.
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What the FDA Data Shows for ixekizumab
The FDA label for ixekizumab (sold under brand names such as Taltz) classifies it as a prescription-only medication in the Anti-IL-17A Monoclonal Antibody class. Taltz is used to treat plaque psoriasis in adults and children 6 years and older. Official labeling lists 4 commonly reported side effects, including Injection site reactions (pain, redness, swelling), Upper respiratory tract infections (like a cold), Nausea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 19,574 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: November 13, 2024
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages