crisaborole
Brand names: Eucrisa
Eucrisa is a medicine used on the skin to treat eczema. It helps reduce swelling and itching.
Drug Pricing (NADAC)
Brand Price
$10.30/unit
Generic Available
No
ANACOR PHARMS INC
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Eucrisa treats mild to moderate atopic dermatitis, also known as eczema.
Common side effects
Pain where you put the medicine
Key warnings
If you have a hypersensitivity reaction, stop using Eucrisa right away.
How It Works
Eucrisa contains crisaborole, which is a phosphodiesterase-4 (PDE4) inhibitor. This medicine works by blocking PDE4. Blocking PDE4 reduces inflammation in the skin, which helps to relieve eczema symptoms.
How to Take It
Apply a thin layer of Eucrisa to the affected areas of your skin. Do this twice a day. After your skin improves, you can consider applying it once a day. Eucrisa is only for use on the skin. Do not put it in your eyes, mouth, or vagina.
Pregnancy & Breastfeeding
Not enough information is available to know if Eucrisa is safe to use during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Eucrisa passes into breast milk, so discuss this with your doctor if you are breastfeeding.
Missed Dose
If you miss a dose, apply it as soon as you remember. Then, continue with your regular schedule.
Storage
Store Eucrisa at room temperature, between 68°F and 77°F. Keep the tube tightly closed.
Side Effects (from patient reports)
Based on 8,417 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 9,400 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2013–2025.
Total Reports
9,400
Death-Related Reports
24
Hospitalization Reports
142
Top Indication
Dermatitis Atopic
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DRUG INEFFECTIVE | 1,957 |
| 2 | APPLICATION SITE PAIN | 1,415 |
| 3 | BURNING SENSATION | 985 |
| 4 | OFF LABEL USE | 746 |
| 5 | CONDITION AGGRAVATED | 699 |
| 6 | PRURITUS | 624 |
| 7 | RASH | 597 |
| 8 | PAIN | 526 |
| 9 | ECZEMA | 447 |
| 10 | DERMATITIS ATOPIC | 421 |
| 11 | ERYTHEMA | 370 |
| 12 | PRODUCT USE IN UNAPPROVED INDICATION | 333 |
| 13 | DRUG HYPERSENSITIVITY | 258 |
| 14 | DRY SKIN | 250 |
| 15 | DRUG INEFFECTIVE FOR UNAPPROVED INDICATION | 241 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
If you have a hypersensitivity reaction, stop using Eucrisa right away. Signs of a reaction include severe itching, swelling, and redness at the application site or somewhere else on your body.
Common Questions
What should I do if Eucrisa does not seem to be working?
Can I use Eucrisa on any part of my body?
How long should I use Eucrisa?
What should I do if I accidentally swallow Eucrisa?
Can I use other skin products while using Eucrisa?
What are the ingredients in Eucrisa?
How often should I apply Eucrisa?
Can children use Eucrisa?
What should I do if I get Eucrisa in my eyes?
Is it okay to use Eucrisa if I am allergic to similar medications?
What are the common side effects of crisaborole?
What drug class is crisaborole?
Is crisaborole safe during pregnancy?
Related Medications in PDE4 Inhibitor (Topical)
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What the FDA Data Shows for crisaborole
The FDA label for crisaborole (sold under brand names such as Eucrisa) classifies it as a prescription-only medication in the PDE4 Inhibitor (Topical) class. Eucrisa treats mild to moderate atopic dermatitis, also known as eczema. Official labeling lists 1 commonly reported side effect, including Pain where you put the medicine.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 8,417 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: September 23, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages