LOW-VOLUME · FEMALE-LED
plecanatide Side Effects
plecanatide (also sold as Trulance) is a LOW-VOLUME FAERS extract #464 of 524 by FAERS report count. Still opens on FEMALE-LED: 79% of sex-coded reports are female (1,154 F / 302 M).
Data updated 2026-05-15
- 1,831
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
plecanatide reporting skew - 79% of sex-coded reports are female (1,154 F / 302 M). Volume band LOW-VOLUME #464 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for plecanatide (Trulance) (1,831 reports #464 of 524 by FAERS report count). 79% of sex-coded reports are female (1,154 F / 302 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2016–2025). Stamps SIGNAL · DEATH-MARKED · HOSP-MID · FEMALE-LED.
DIARRHOEA leads 363 of 1,831 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (79% of sex-coded rows)
Age peak 45-64 (347 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death appears on 72 reports (3.9% - MARKED). Reactions below co-occur in those rows only.
| Reaction | Reports |
|---|---|
| DEATH | 60 |
| CONSTIPATION | 5 |
| ASTHENIA | 3 |
| FALL | 3 |
| HALLUCINATION | 3 |
| TREMOR | 3 |
| ABDOMINAL DISTENSION | 2 |
| ANKLE FRACTURE | 2 |
| CARDIAC ARREST | 2 |
| CARDIAC DISORDER | 2 |
| COLITIS ULCERATIVE | 2 |
| DYSPNOEA | 2 |
| FATIGUE | 2 |
| GAIT DISTURBANCE | 2 |
| INSURANCE ISSUE | 2 |
| LACTIC ACIDOSIS | 2 |
| LUNG DISORDER | 2 |
| MOBILITY DECREASED | 2 |
| MUSCULAR WEAKNESS | 2 |
Reactions in Hospitalization Reports
Hospitalization mid-share (254, 13.9%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| NAUSEA | 33 |
| FALL | 31 |
| DIARRHOEA | 30 |
| CONSTIPATION | 25 |
| FATIGUE | 24 |
| HEADACHE | 24 |
| HOSPITALISATION | 24 |
| DIZZINESS | 21 |
| PAIN | 21 |
| COVID-19 | 20 |
| DYSPNOEA | 18 |
| MALAISE | 16 |
| PNEUMONIA | 16 |
| URINARY TRACT INFECTION | 16 |
| ABDOMINAL PAIN | 15 |
| ILLNESS | 14 |
| VOMITING | 14 |
| ABDOMINAL PAIN UPPER | 13 |
How to read plecanatide FAERS figures (SIGNAL · DEATH-MARKED · HOSP-MID)
FAERS holds 1,831 voluntary reports linked to plecanatide (Trulance), 2016-2025. Death is listed on 72 (3.9%). Hospitalization appears on 254 (13.9%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and FEMALE-LED skew still differ by drug; not a complete safety profile.
Read with plecanatide
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-MARKED · HOSP-MID stamps.
ABS(total_reports) peer at 1,829 FAERS cases (Δ 2 lighter vs plecanatide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 1,858 FAERS cases (Δ 27 heavier vs plecanatide); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 1,797 FAERS cases (Δ 34 lighter vs plecanatide); DEATH-MARKED · HOSP-LIGHT · SEX-BALANCED vs this page's SIGNAL · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 1,890 FAERS cases (Δ 59 heavier vs plecanatide); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's SIGNAL · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 58.2 pp vs plecanatide's DEATH-MARKED): CASELOAD · HOSP-MID.
plecanatide stamps SIGNAL · FEMALE-LED; class peers and methodology beat restating the same FAERS caveats on every effects URL.