HIGH-VOLUME · FEMALE-LED
estradiol Side Effects
estradiol (also sold as Estrace, Vivelle-Dot) is HIGH-VOLUME in this FAERS book #90 of 524 by FAERS report count. Signature opener: FEMALE-LED - 99% of sex-coded reports are female (76,881 F / 1,040 M).
Data updated 2026-05-15
- 83,781
- FAERS reports
FAERS voluntary reports, 2000 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
estradiol reporting skew - 99% of sex-coded reports are female (76,881 F / 1,040 M). Volume band HIGH-VOLUME #90 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for estradiol (Estrace): 83,781 FAERS rows (2000-2025). Top named reactions: PRODUCT ADHESION ISSUE, HEADACHE, NAUSEA. Outcome stamps DEATH-MARKED · HOSP-MID · FEMALE-LED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2000–2025). Stamps CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
PRODUCT ADHESION ISSUE leads 5,172 of 83,781 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (99% of sex-coded rows)
Age peak 45-64 (25,450 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death appears on 1,484 reports (1.8% - MARKED). Reactions below co-occur in those rows only.
| Reaction | Reports |
|---|---|
| DEATH | 528 |
| COMPLETED SUICIDE | 99 |
| PNEUMONIA | 86 |
| PAIN | 80 |
| DYSPNOEA | 76 |
| NAUSEA | 73 |
| FATIGUE | 69 |
| RENAL FAILURE | 63 |
| DIARRHOEA | 62 |
| CONDITION AGGRAVATED | 59 |
| FALL | 59 |
| VOMITING | 58 |
| CEREBROVASCULAR ACCIDENT | 56 |
| CHEST PAIN | 54 |
| MALAISE | 52 |
| ACUTE KIDNEY INJURY | 51 |
| ANAEMIA | 50 |
| ANXIETY | 50 |
| RESPIRATORY FAILURE | 50 |
Reactions in Hospitalization Reports
Hospitalization mid-share (11,279, 13.5%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| NAUSEA | 1,024 |
| FATIGUE | 901 |
| DIARRHOEA | 823 |
| PAIN | 821 |
| DYSPNOEA | 816 |
| HEADACHE | 761 |
| FALL | 737 |
| VOMITING | 706 |
| PNEUMONIA | 637 |
| URINARY TRACT INFECTION | 599 |
| DIZZINESS | 589 |
| ASTHENIA | 586 |
| MALAISE | 561 |
| ARTHRALGIA | 542 |
| WEIGHT DECREASED | 516 |
| ABDOMINAL PAIN | 503 |
| DEPRESSION | 484 |
| PYREXIA | 478 |
How to read estradiol FAERS figures (CASELOAD · DEATH-MARKED · HOSP-MID)
FAERS holds 83,781 voluntary reports linked to estradiol (Estrace, Vivelle-Dot), 2000-2025. Death is listed on 1,484 (1.8%). Hospitalization appears on 11,279 (13.5%). Top co-reported indication: Product Used For Unknown Indication.
CASELOAD books overweight common drugs and loud reporting cultures; FEMALE-LED is the page opener, not a per-patient risk.
Read with estradiol
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-MARKED · HOSP-MID stamps.
ABS(total_reports) peer at 83,476 FAERS cases (Δ 305 lighter vs estradiol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 84,725 FAERS cases (Δ 944 heavier vs estradiol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 82,622 FAERS cases (Δ 1,159 lighter vs estradiol); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 82,165 FAERS cases (Δ 1,616 lighter vs estradiol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-MARKED · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 60.3 pp vs estradiol's DEATH-MARKED): CASELOAD · HOSP-MID.
estradiol sits in CASELOAD; high report volume tracks exposure and reporting culture more than per-patient risk. Methodology states the de-dup rules.