tetracycline vs theophylline

According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.

Side-by-side comparison of tetracycline and theophylline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

major Known Drug Interaction

albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...

Drug Class
tetracycline Tetracycline Antibiotic
theophylline Methylxanthine Bronchodilator
Type
tetracycline Prescription
theophylline Prescription
Summary
tetracycline

Tetracycline is an antibiotic medicine. It fights bacteria in your body to treat different types of infections.

theophylline

Theophylline is a medicine that helps you breathe easier. It treats the symptoms of asthma and other lung problems.

What It Treats
tetracycline

Tetracycline treats many kinds of infections caused by bacteria. This includes infections of the lungs, skin, urinary tract, and some sexually transmitted infections. It can also treat acne and other less common infections like brucellosis, tularemia, or cholera. Your doctor will decide if tetracycline is right for your infection.

theophylline

Theophylline treats the symptoms of long-term asthma and other lung diseases. These include emphysema and chronic bronchitis, which make it hard to breathe. This medicine helps to open up your airways so you can breathe easier.

How It Works
tetracycline

Tetracycline works by stopping bacteria from growing and multiplying. It prevents the bacteria from making proteins they need to survive. This helps your body's immune system fight off the infection.

theophylline

Theophylline is a bronchodilator. It works by relaxing the muscles in your airways. This allows more air to flow in and out of your lungs.

Common Side Effects
tetracycline
  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Stomach upset
theophylline
  • Nausea
  • Vomiting
  • Headache
  • Trouble sleeping (insomnia)
FAERS Reports
tetracycline
  • Drug Hypersensitivity 151
  • Hypersensitivity 123
  • Pneumonia 103
  • Pain In Extremity 93
  • Arthralgia 90
theophylline
  • Dyspnoea 2,273
  • Asthma 1,942
  • Pneumonia 1,318
  • Wheezing 1,306
  • Vomiting 1,101
Serious Warnings
tetracycline

Tetracycline can cause permanent tooth discoloration if used during tooth development. This means it should not be used in pregnant women or children under 8 years old. Tetracycline can also make your skin more sensitive to the sun, so avoid prolonged sun exposure.

theophylline

If your theophylline levels get too high in your blood, it can cause serious side effects. These include severe vomiting, irregular heartbeats, and seizures. These can be life-threatening.

Pregnancy
tetracycline

Tetracycline can harm an unborn baby. You should not take tetracycline if you are pregnant. Tetracycline can also pass into breast milk and may affect the baby. Talk to your doctor about safe alternatives if you are breastfeeding.

theophylline

It is not known if theophylline can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if theophylline passes into breast milk, so talk to your doctor if you are breastfeeding.

Also Compare, Nearby Drugs

How to Read This tetracycline vs theophylline Comparison

tetracycline is classified in the Tetracycline Antibiotic drug class, while theophylline sits within the Methylxanthine Bronchodilator class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, tetracycline has 560 submissions while theophylline has 7,940. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to this antibiotic does not significantly change how fast your liver breaks down theophylline, so the drug levels in your blood should stay the same.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for tetracycline or theophylline.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.