rifampin vs vilazodone
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of rifampin and vilazodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Strong CYP3A4 Inducers (e.g., carbamazepine, phenytoin, rifampin) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inducers decreased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Rifadin
Viibryd
Rifampin is an antibiotic medicine. It fights bacteria in your body to treat infections.
Vilazodone (Viibryd) is a medicine used to treat depression in adults. It helps to improve your mood.
Rifampin treats tuberculosis (TB) and helps eliminate the bacteria that cause meningitis from your nose and throat. It is important to use rifampin only for infections that are proven or strongly suspected to be caused by bacteria. This helps to prevent bacteria from becoming resistant to the medicine.
Vilazodone is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve these symptoms.
Rifampin works by stopping bacteria from growing and multiplying. It does this by blocking a key enzyme that the bacteria need to make proteins. This helps your body fight off the infection.
Vilazodone works by affecting certain chemicals in the brain. It increases the amount of serotonin available. Serotonin helps to regulate mood and emotions.
- • Heartburn
- • Upset stomach
- • Loss of appetite
- • Nausea
- • Vomiting
- • Diarrhea
- • Nausea
- • Vomiting
- • Trouble sleeping (insomnia)
- Drug Interaction 970
- Drug Reaction With Eosinophilia And Systemic Symptoms 727
- Nausea 628
- Condition Aggravated 550
- Pyrexia 541
- Diarrhoea 808
- Nausea 808
- Anxiety 662
- Insomnia 634
- Headache 565
Rifampin can cause liver problems. Tell your doctor right away if you have yellowing of the skin or eyes, dark urine, or stomach pain. Rifampin can also cause blood problems. Tell your doctor if you have unusual bleeding or bruising.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely monitor you for worsening depression or suicidal thoughts, especially when you first start taking this medicine or when your dose is changed. Vilazodone is not approved for use in children.
Tell your doctor if you are pregnant or plan to become pregnant. Rifampin can make birth control pills less effective, so use other forms of birth control. Talk to your doctor if you are breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Taking vilazodone late in pregnancy may cause problems for the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can call 1-844-405-6185 to register.
How to Read This rifampin vs vilazodone Comparison
rifampin is classified in the Rifamycin Antibiotic drug class, while vilazodone sits within the SSRI / 5-HT1A Partial Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, rifampin has 3,416 submissions while vilazodone has 3,477. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to rifampin causes your body to process and remove vilazodone much faster than normal. this can lower the amount of medicine in your blood and make it work less effectively.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for rifampin or vilazodone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.