quetiapine vs rifampin
Side-by-side comparison of quetiapine and rifampin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Concomitant use of strong CYP3A4 inhibitors: Reduce quetiapine dose to one sixth when coadministered with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) ( 2.5 , 7.1 , 12.3 ) Concomitant use of strong CYP3A4 inducers: Increase quetiapine dose up to 5 fold when used in combination with a chronic treatment (more than 7-14 days) of potent CYP3A4 inducers (e.g., phenytoin, rifampin, St. Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4...
Recommendation: Your doctor may need to increase your quetiapine dose up to five times the normal amount if you take these together for more than a week.
Seroquel
Rifadin
Quetiapine is a medicine that belongs to a class of drugs called atypical antipsychotics. It is used to treat mental disorders like schizophrenia and bipolar disorder.
Rifampin is an antibiotic medicine. It fights bacteria in your body to treat infections.
Quetiapine is used to treat schizophrenia in adults and teens (13-17 years old). It also treats manic and depressive episodes of bipolar disorder in adults and children (10-17 years old). For bipolar disorder, it can be used alone or with other medicines like lithium or divalproex.
Rifampin treats tuberculosis (TB) and helps eliminate the bacteria that cause meningitis from your nose and throat. It is important to use rifampin only for infections that are proven or strongly suspected to be caused by bacteria. This helps to prevent bacteria from becoming resistant to the medicine.
Quetiapine works by changing the levels of certain natural substances in the brain. These substances are called neurotransmitters. By affecting these neurotransmitters, quetiapine can help reduce symptoms of mental disorders.
Rifampin works by stopping bacteria from growing and multiplying. It does this by blocking a key enzyme that the bacteria need to make proteins. This helps your body fight off the infection.
- • Feeling sleepy
- • Dry mouth
- • Dizziness
- • Constipation
- • Feeling weak
- • Heartburn
- • Upset stomach
- • Loss of appetite
- • Nausea
- • Vomiting
- Harmful effects from different substances 9,721
- Trouble sleeping 9,103
- Feeling tired 8,861
- Diabetes 8,343
- Weight gain 8,153
- Drug Interaction 970
- Drug Reaction With Eosinophilia And Systemic Symptoms 727
- Nausea 628
- Condition Aggravated 550
- Pyrexia 541
Quetiapine may increase the risk of death in elderly patients who have psychosis related to dementia. Quetiapine can also increase the risk of suicidal thoughts and behavior in children, teens, and young adults. Watch for worsening symptoms or suicidal thoughts, and tell your doctor right away.
Rifampin can cause liver problems. Tell your doctor right away if you have yellowing of the skin or eyes, dark urine, or stomach pain. Rifampin can also cause blood problems. Tell your doctor if you have unusual bleeding or bruising.
If you take quetiapine during the last 3 months of pregnancy, your baby may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to track outcomes in women who take quetiapine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are pregnant or plan to become pregnant. Rifampin can make birth control pills less effective, so use other forms of birth control. Talk to your doctor if you are breastfeeding.
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How to Read This quetiapine vs rifampin Comparison
quetiapine is classified in the Atypical Antipsychotic drug class, while rifampin sits within the Rifamycin Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, quetiapine has 44,181 submissions while rifampin has 3,416. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to rifampin speeds up the process of your body breaking down quetiapine, which lowers the amount of medicine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between quetiapine and rifampin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.