propafenone vs tizanidine
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of propafenone and tizanidine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.2 Moderate or Weak CYP1A2 Inhibitors Concomitant use of tizanidine with moderate or weak CYP1A2 inhibitors (e.g., zileuton, antiarrhythmics [amiodarone, mexiletine, propafenone, and verapamil], cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided.
Rythmol
Zanaflex
Propafenone (Rythmol) is a medicine that helps control irregular heartbeats. It works by slowing down electrical signals in the heart.
Tizanidine is a muscle relaxant. It is used to treat spasticity, which is when your muscles are tight or stiff.
This medicine is used to help keep your heart rhythm normal if you have atrial fibrillation or supraventricular tachycardia. These are types of fast or irregular heartbeats that can cause problems. It can also treat life-threatening ventricular arrhythmias. Propafenone is for people without structural heart disease.
Tizanidine is used to treat spasticity in adults. Spasticity is a condition where your muscles become stiff or tight. This medicine helps to relax your muscles and reduce the stiffness. It can help you move and feel more comfortable.
Propafenone works by affecting the electrical activity in your heart. It slows down the signals that cause irregular heartbeats. This helps your heart beat more regularly.
Tizanidine works by affecting certain chemicals in your brain. It is an alpha-2 adrenergic agonist. This action helps to reduce muscle spasms and tightness.
- • Unusual taste
- • Nausea
- • Vomiting
- • Dizziness
- • Constipation
- • Dry mouth
- • Sleepiness
- • Weakness
- • Dizziness
- Atrial Fibrillation 347
- Drug Interaction 320
- Dizziness 262
- Toxicity To Various Agents 231
- Dyspnoea 226
- Fatigue 1,693
- Pain 1,614
- Nausea 1,529
- Fall 1,318
- Headache 1,289
This medicine may increase the risk of death in people with heart problems. Do not take this medicine if you have structural heart disease and non-life-threatening ventricular arrhythmias. Talk to your doctor about the risks and benefits of taking this medicine.
Tizanidine can cause low blood pressure, liver problems, and hallucinations. It can also make you very sleepy, especially if you drink alcohol or take other medicines that cause sleepiness. Your doctor should check your liver function before you start taking tizanidine and one month after you reach your highest dose. Do not stop taking tizanidine suddenly, as this can cause withdrawal symptoms.
Tell your doctor if you are pregnant or plan to become pregnant. This medicine can cross the placenta, and may affect the baby. Your doctor will monitor you and your baby for any problems.
Tizanidine may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if tizanidine passes into breast milk, so talk to your doctor if you are breastfeeding.
Also Compare, Nearby Drugs
Compare propafenone with
How to Read This propafenone vs tizanidine Comparison
propafenone is classified in the Class IC Antiarrhythmic drug class, while tizanidine sits within the Central Alpha-2 Agonist (Muscle Relaxant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, propafenone has 1,386 submissions while tizanidine has 7,443. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to propafenone interferes with how your body processes tizanidine, making the drug stay in your blood longer than it should.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for propafenone or tizanidine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.