prednisone vs theophylline

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Side-by-side comparison of prednisone and theophylline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

major Known Drug Interaction

albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...

Drug Class
prednisone Corticosteroid
theophylline Methylxanthine Bronchodilator
Type
prednisone Prescription
theophylline Prescription
Summary
prednisone

Prednisone is a steroid medicine that reduces inflammation in the body. It can treat many different conditions.

theophylline

Theophylline is a medicine that helps you breathe easier. It treats the symptoms of asthma and other lung problems.

What It Treats
prednisone

Prednisone treats conditions like arthritis, severe allergies, asthma, skin problems, and certain cancers. It can also help with lung diseases and problems with your hormone levels. Prednisone can also be used to reduce protein in the urine due to kidney problems.

theophylline

Theophylline treats the symptoms of long-term asthma and other lung diseases. These include emphysema and chronic bronchitis, which make it hard to breathe. This medicine helps to open up your airways so you can breathe easier.

How It Works
prednisone

Prednisone is a corticosteroid that works by decreasing inflammation. It suppresses your immune system, which reduces swelling and other immune responses. This helps control the symptoms of various diseases.

theophylline

Theophylline is a bronchodilator. It works by relaxing the muscles in your airways. This allows more air to flow in and out of your lungs.

Common Side Effects
prednisone
  • Fluid retention
  • Mood changes
  • Weight gain
  • Increased appetite
  • High blood pressure
theophylline
  • Nausea
  • Vomiting
  • Headache
  • Trouble sleeping (insomnia)
FAERS Reports
prednisone
  • Fatigue 39,612
  • Pain 36,926
  • Dyspnoea 33,819
  • Arthralgia 32,404
  • Condition Aggravated 27,784
theophylline
  • Dyspnoea 2,273
  • Asthma 1,942
  • Pneumonia 1,318
  • Wheezing 1,306
  • Vomiting 1,101
Serious Warnings
prednisone

If you take prednisone for a long time, your body may not produce enough of its own natural steroids. This can make it hard for your body to respond to stress, like during an illness or surgery. You should not stop taking prednisone suddenly, as this can cause serious withdrawal symptoms.

theophylline

If your theophylline levels get too high in your blood, it can cause serious side effects. These include severe vomiting, irregular heartbeats, and seizures. These can be life-threatening.

Pregnancy
prednisone

Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Prednisone may harm an unborn baby. It can also pass into breast milk and may affect the nursing infant.

theophylline

It is not known if theophylline can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if theophylline passes into breast milk, so talk to your doctor if you are breastfeeding.

Also Compare, Nearby Drugs

How to Read This prednisone vs theophylline Comparison

prednisone is classified in the Corticosteroid drug class, while theophylline sits within the Methylxanthine Bronchodilator class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, prednisone has 170,545 submissions while theophylline has 7,940. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to prednisone does not change the speed at which theophylline leaves your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for prednisone or theophylline.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.