midazolam vs tacrolimus topical
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of midazolam and tacrolimus topical. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Strong CYP3A Inducers Strong CYP3A inhibitor/inducer, based on reported effect on exposures to tacrolimus along with supporting in vitro CYP3A inhibitor/inducer data, or based on drug-drug interaction studies with midazolam (sensitive CYP3A probe substrate).
Versed
Protopic
Midazolam is a medicine that makes you feel calm, relaxed, and sleepy. It can also cause you to forget things that happen while you are taking it.
Tacrolimus extended-release capsules help prevent organ rejection in kidney transplant patients. It works by suppressing your immune system.
Midazolam is used to sedate you before a surgery or procedure to help you relax and feel less anxious. It can also be used to help you feel calm during procedures like bronchoscopies or endoscopies. Midazolam can also be used to start general anesthesia before you get other medicines.
This medicine is used to prevent your body from rejecting a new kidney after a transplant. It is for adult patients who can swallow capsules whole. You will take it with other medicines that also suppress your immune system.
Midazolam belongs to a class of drugs called benzodiazepines. It works by slowing down activity in your brain and nervous system. This helps to reduce anxiety, promote relaxation, and cause sleepiness.
Tacrolimus belongs to a class of drugs called calcineurin inhibitors. It lowers the activity of your immune system. This helps prevent your body from attacking your new kidney.
- • Decreased breathing rate
- • Tenderness at the injection site
- • Pain during injection
- • Diarrhea
- • Constipation
- • Nausea
- • Swelling in your arms and legs
- • Tremors
- Seizure 1,373
- Hypotension 1,296
- Drug Interaction 1,088
- Toxicity To Various Agents 846
- Acute Kidney Injury 845
No adverse event reports.
Midazolam can cause serious breathing problems, including slowed or stopped breathing. This is more likely to happen if you are also taking opioid pain medicines. You must be closely monitored by trained medical staff while receiving midazolam. Make sure the facility has the equipment and medicines needed to treat breathing problems immediately.
This medicine can increase your risk of serious infections and certain cancers. These problems could lead to hospitalization or even death. This drug is not approved for liver transplants and may increase the risk of death in female liver transplant patients.
Tell your doctor if you are pregnant or plan to become pregnant. Midazolam may harm an unborn baby. It is not known if midazolam passes into breast milk. Talk to your doctor about the risks and benefits of using this medicine while breastfeeding.
Tacrolimus can harm your unborn baby. Tell your doctor right away if you are pregnant or plan to become pregnant. There is a pregnancy registry to track outcomes in women who take tacrolimus during pregnancy.
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How to Read This midazolam vs tacrolimus topical Comparison
midazolam is classified in the Benzodiazepine drug class, while tacrolimus topical sits within the Calcineurin Inhibitor (Topical) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, midazolam has 5,448 submissions while tacrolimus topical has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs use the same pathway in the liver to leave the body, so taking them together can interfere with how they are processed.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for midazolam or tacrolimus topical.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.