metaxalone vs norepinephrine
Side-by-side comparison of metaxalone and norepinephrine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples of serotonergic drugs include: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, opioids (particularly fentanyl, meperidine, and methadone), drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Recommendation: Use this combination with caution and tell your doctor immediately if you feel agitated, dizzy, or have a fast heartbeat.
Skelaxin
Levophed
Metaxalone is a muscle relaxant. It helps relieve discomfort from painful muscle and bone problems.
Norepinephrine injection raises blood pressure in adults with very low blood pressure. It belongs to a class of drugs called vasopressors.
Metaxalone treats the pain and discomfort caused by muscle problems. It is used along with rest and physical therapy. It does not directly relax your muscles, but it can make you feel sleepy, which may help.
This medicine treats severe, sudden low blood pressure in adults. Low blood pressure can happen due to serious conditions. Norepinephrine helps to restore blood pressure to help blood flow to vital organs.
The exact way metaxalone works is not fully known. It is thought to work by making you feel sleepy. This can help to relieve muscle pain.
Norepinephrine works by tightening blood vessels. This increases blood pressure. It helps to improve blood flow to your organs.
- • Drowsiness
- • Dizziness
- • Headache
- • Nervousness or irritability
- • Nausea
- • High blood pressure
- • Slow heart rate
- • Anxiety
- • Headache
- • Trouble breathing
- Suicide 261
- Tiredness 196
- Pain 195
- Feeling sick to your stomach 190
- Headache 166
- Low blood pressure 1,011
- Sudden kidney damage 747
- Failure of multiple organs 652
- Poisoning from different substances 624
- Condition getting worse 560
Metaxalone can cause sleepiness. Do not drive or operate heavy machinery until you know how it affects you. Using metaxalone with alcohol, opioids, or other drugs that cause sleepiness can be dangerous. A potentially life-threatening condition called serotonin syndrome has been reported when metaxalone is used with certain other drugs.
Norepinephrine can cause tissue damage if it leaks out of the vein. The medicine can also cause very low blood pressure if stopped suddenly. It may also cause irregular heartbeats, especially if you have heart problems. Allergic reactions are possible due to the sulfite ingredient.
It is not known if metaxalone can harm an unborn baby. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
This medicine may be used during pregnancy if needed. Low blood pressure during pregnancy can be dangerous for both mother and baby. Talk to your doctor about the risks and benefits.
Also Compare, Nearby Drugs
Compare metaxalone with
How to Read This metaxalone vs norepinephrine Comparison
metaxalone is classified in the Muscle Relaxant drug class, while norepinephrine sits within the Vasopressor (Alpha-1 Agonist) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, metaxalone has 1,008 submissions while norepinephrine has 3,594. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medications both affect the chemical systems in your brain and nerves. using them at the same time can lead to an unhealthy buildup of serotonin.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between metaxalone and norepinephrine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.