magnesium oxide vs naproxen
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Side-by-side comparison of magnesium oxide and naproxen. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Antacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen. Intervention: Concomitant administration of antacids such as magnesium oxide or aluminum hydroxide, and sucralfate with naproxen tablets and naproxen sodium tablets is not recommended.
Mag-Ox
Aleve, Naprosyn
Magnesium oxide (Mag-Ox) is a mineral supplement. It helps relieve acid indigestion and upset stomach.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It helps reduce pain, swelling, and stiffness.
Mag-Ox treats acid indigestion and upset stomach. It works by reducing the amount of acid in your stomach. Talk to your doctor if your symptoms do not improve.
Naproxen is used to relieve pain and inflammation. You can use it for arthritis, including rheumatoid arthritis and osteoarthritis. It also treats ankylosing spondylitis and juvenile idiopathic arthritis. Naproxen can help with tendonitis, bursitis, gout, menstrual cramps, and general pain.
Mag-Ox contains magnesium oxide, which neutralizes stomach acid. This helps to reduce discomfort caused by excess acid. It provides relief from indigestion and upset stomach.
Naproxen works by reducing substances in the body that cause pain and inflammation. It blocks the production of prostaglandins. These substances contribute to the symptoms of pain, swelling, and fever.
- • Diarrhea
- • Heartburn
- • Abdominal pain
- • Nausea
- • Constipation
- • Diarrhea
- Nausea 2,795
- Diarrhoea 2,580
- Fatigue 2,419
- Dyspnoea 2,054
- Pneumonia 2,029
- Pain 8,756
- Fatigue 7,339
- Arthralgia 7,243
- Nausea 7,062
- Headache 5,716
No specific warnings noted.
Naproxen may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take naproxen if you are having heart bypass surgery. Naproxen can also increase your risk of serious stomach and intestine problems, including bleeding, ulcers, and holes, which can be fatal. These problems can occur without warning. Elderly people are at higher risk.
Talk to your doctor before taking Mag-Ox if you are pregnant or breastfeeding. They can help you weigh the risks and benefits.
Using naproxen after 20 weeks of pregnancy can cause kidney problems in the unborn baby, leading to low amniotic fluid. Avoid using naproxen at 30 weeks of pregnancy or later because it can cause the baby's heart to close too early. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This magnesium oxide vs naproxen Comparison
magnesium oxide is classified in the Mineral Supplement drug class, while naproxen sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are available over the counter.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, magnesium oxide has 11,877 submissions while naproxen has 36,116. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to magnesium oxide can slow down how quickly your body absorbs naproxen into your bloodstream. this might make the naproxen take longer to start working.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for magnesium oxide or naproxen.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.