lisinopril vs ramipril
Side-by-side comparison of lisinopril and ramipril Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
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Lisinopril and hydrochlorothiazide is a drug that lowers blood pressure. It contains two medicines that work together to help your heart.
Ramipril is a medicine that lowers blood pressure. It can also help people with heart failure after a heart attack.
This medicine treats high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks. You should also manage cholesterol, diabetes, and quit smoking to improve your heart health.
Ramipril is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. It is also used in patients who have signs of heart failure after a heart attack. Ramipril can lower the risk of death and hospitalization in these patients.
Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water. Together, they lower blood pressure more effectively.
Ramipril belongs to a class of drugs called ACE inhibitors. It works by blocking a substance in your body that tightens blood vessels. This helps your blood vessels relax and lowers your blood pressure.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- • Headache
- • Dizziness
- • Fatigue
- • Cough
- Feeling tired 19,347
- Feeling sick to your stomach 17,995
- The medicine is not working 17,182
- Loose stools 16,772
- Difficulty breathing 13,649
- Difficulty breathing 8,083
- Tiredness 7,876
- Feeling sick to your stomach 7,337
- Loose stools 6,914
- Feeling lightheaded 6,526
This drug can harm your unborn baby, even causing death. Stop taking this medicine as soon as you know you are pregnant.
This drug can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, tell your doctor right away. Stop taking ramipril as soon as you know you are pregnant.
Do not take this medicine if you are pregnant. It can cause serious harm or death to your unborn baby. Talk to your doctor about safe alternatives if you are breastfeeding.
Do not take ramipril if you are pregnant. It can harm your unborn baby. It is not recommended to use ramipril if you are breastfeeding.
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How to Read This lisinopril vs ramipril Comparison
lisinopril is classified in the ACE Inhibitor drug class, while ramipril sits within the ACE Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lisinopril has 84,945 submissions while ramipril has 36,736. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between lisinopril and ramipril — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.