ketoconazole vs venlafaxine
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Side-by-side comparison of ketoconazole and venlafaxine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Ketoconazole A pharmacokinetic study with ketoconazole 100 mg b.i.d. with a single dose of venlafaxine 50 mg in extensive metabolizers (EM; n = 14) and 25 mg in poor metabolizers (PM; n = 6) of CYP2D6 resulted in higher plasma concentrations of both venlafaxine and O-desvenlafaxine (ODV) in most subjects following administration of ketoconazole.
Nizoral
Effexor, Effexor XR
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Venlafaxine is a medication used to treat depression. It helps to improve your mood by affecting certain chemicals in the brain.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Venlafaxine is used to treat major depressive disorder. This condition can cause a persistent feeling of sadness or loss of interest in daily activities. It may also help maintain improvement in patients with recurrent depression.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine in the brain. These chemicals help regulate mood and can be low in people with depression.
No common side effects listed.
- • Feeling weak or tired
- • Sweating a lot
- • Feeling sick to your stomach
- • Constipation
- • Loss of appetite
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Nausea 4,298
- Toxicity To Various Agents 4,265
- Fatigue 4,198
- Headache 3,740
- Completed Suicide 3,169
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Your doctor will monitor you closely for worsening depression, suicidal thoughts, or unusual changes in behavior. Venlafaxine is not approved for use in children.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
If you are pregnant or breastfeeding, talk to your doctor before taking venlafaxine. Newborns exposed to SNRIs like venlafaxine in the third trimester may have complications requiring hospitalization. Your doctor will carefully consider the risks and benefits of treatment during pregnancy.
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How to Read This ketoconazole vs venlafaxine Comparison
ketoconazole is classified in the Azole Antifungal drug class, while venlafaxine sits within the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while venlafaxine has 19,670. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole blocks the enzymes that break down venlafaxine, which causes the level of the medicine to rise in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or venlafaxine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.