ketoconazole vs ramelteon
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Side-by-side comparison of ketoconazole and ramelteon. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
( 7.1 ) Ketoconazole (strong CYP3A4 inhibitor): Increases AUC for ramelteon; administer with caution. Ketoconazole (strong CYP3A4 inhibitor) The AUC 0-inf and C max of ramelteon increased by approximately 84% and 36% upon coadministration of ketoconazole with ramelteon. Ramelteon should be administered with caution in subjects taking strong CYP3A4 inhibitors such as ketoconazole [see Clinical Pharmacology (12.5) ] .
Nizoral
Rozerem
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Ramelteon (Rozerem) is a prescription medicine that can help you fall asleep faster. It works by acting like a natural hormone in your brain that regulates sleep.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Ramelteon is used to treat insomnia when you have trouble falling asleep. It can help you fall asleep faster so you can get a better night's rest. Studies have shown it works for up to six months.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Ramelteon works by targeting receptors in your brain that are involved in the sleep-wake cycle. It acts like melatonin, a hormone your body makes naturally to help you sleep. By binding to these receptors, ramelteon helps to promote sleepiness.
No common side effects listed.
- • Feeling sleepy
- • Dizziness
- • Feeling tired
- • Nausea
- • Worsening insomnia
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Initial Insomnia 447
- Somnolence 411
- Middle Insomnia 390
- Insomnia 388
- Nausea 327
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Rarely, some people have had severe allergic reactions (angioedema and anaphylaxis) with throat closing, trouble breathing, nausea, or vomiting. If this happens, stop taking ramelteon and get medical help right away. Do not take ramelteon again if you've had this type of reaction to it. Ramelteon may cause changes in behavior, such as sleep-driving or hallucinations. It may also worsen depression or cause suicidal thoughts. Be careful driving or operating machinery, as ramelteon can affect your alertness.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
Talk to your doctor if you are pregnant or plan to become pregnant. Animal studies suggest a risk of birth defects at high doses. It is not known if ramelteon passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine, and watch for sleepiness or feeding problems in the baby.
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How to Read This ketoconazole vs ramelteon Comparison
ketoconazole is classified in the Azole Antifungal drug class, while ramelteon sits within the Melatonin Receptor Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while ramelteon has 1,963. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to ketoconazole blocks the enzyme that breaks down ramelteon, which causes the sleep medicine to build up in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or ramelteon.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.