ketoconazole vs quetiapine
Side-by-side comparison of ketoconazole and quetiapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Concomitant use of strong CYP3A4 inhibitors: Reduce quetiapine dose to one sixth when coadministered with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) ( 2.5 , 7.1 , 12.3 ) Concomitant use of strong CYP3A4 inducers: Increase quetiapine dose up to 5 fold when used in combination with a chronic treatment (more than 7-14 days) of potent CYP3A4 inducers (e.g., phenytoin, rifampin, St. Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4...
Recommendation: Your doctor should reduce your quetiapine dose to one-sixth of the original amount when taking it with ketoconazole.
Nizoral
Seroquel
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Quetiapine is a medicine that belongs to a class of drugs called atypical antipsychotics. It is used to treat mental disorders like schizophrenia and bipolar disorder.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Quetiapine is used to treat schizophrenia in adults and teens (13-17 years old). It also treats manic and depressive episodes of bipolar disorder in adults and children (10-17 years old). For bipolar disorder, it can be used alone or with other medicines like lithium or divalproex.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Quetiapine works by changing the levels of certain natural substances in the brain. These substances are called neurotransmitters. By affecting these neurotransmitters, quetiapine can help reduce symptoms of mental disorders.
No common side effects listed.
- • Feeling sleepy
- • Dry mouth
- • Dizziness
- • Constipation
- • Feeling weak
- Feeling tired 929
- Itching 902
- Feeling sick to your stomach 834
- Skin breakout 802
- Loose stool 760
- Harmful effects from different substances 9,721
- Trouble sleeping 9,103
- Feeling tired 8,861
- Diabetes 8,343
- Weight gain 8,153
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Quetiapine may increase the risk of death in elderly patients who have psychosis related to dementia. Quetiapine can also increase the risk of suicidal thoughts and behavior in children, teens, and young adults. Watch for worsening symptoms or suicidal thoughts, and tell your doctor right away.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
If you take quetiapine during the last 3 months of pregnancy, your baby may have withdrawal symptoms or other problems after birth. There is a pregnancy registry to track outcomes in women who take quetiapine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This ketoconazole vs quetiapine Comparison
ketoconazole is classified in the Azole Antifungal drug class, while quetiapine sits within the Atypical Antipsychotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while quetiapine has 44,181. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole slows down the body's ability to break down quetiapine, which causes the level of quetiapine in your blood to rise significantly. this increase can lead to a higher risk of side effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between ketoconazole and quetiapine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.