ketoconazole vs oxybutynin
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Side-by-side comparison of ketoconazole and oxybutynin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Mean oxybutynin chloride plasma concentrations were approximately 2 fold higher when Oxybutynin chloride extended-release tablets were administered with ketoconazole, a potent CYP3A4 inhibitor. (7) Co-administration with strong cytochrome P450 (CYP) 3A4 inhibitors (e.g., ketoconazole) increases the systemic exposure of oxybutynin.
Nizoral
Ditropan
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Oxybutynin extended-release tablets help control an overactive bladder. It reduces the feeling of needing to go to the bathroom often.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
This medicine treats overactive bladder. It helps with symptoms like needing to urinate frequently, feeling a sudden urge to urinate, and leaking urine. It can also treat overactive bladder in children 6 years and older caused by nerve problems.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Oxybutynin belongs to a class of drugs called antimuscarinics. It works by relaxing the bladder muscles. This helps to decrease the urge to urinate and prevent leakage.
No common side effects listed.
- • Dry mouth
- • Constipation
- • Diarrhea
- • Headache
- • Feeling sleepy
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Fatigue 1,539
- Fall 1,467
- Nausea 1,211
- Dizziness 1,144
- Diarrhoea 1,079
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Oxybutynin can cause swelling of the face, lips, tongue, and throat (angioedema). If this happens, stop taking the medicine right away and get medical help. This medicine can also cause confusion, hallucinations, and drowsiness. Be careful driving or operating machinery until you know how it affects you. Use caution if you have dementia, Parkinson's disease, myasthenia gravis, or decreased gut motility.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor if you are breastfeeding.
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How to Read This ketoconazole vs oxybutynin Comparison
ketoconazole is classified in the Azole Antifungal drug class, while oxybutynin sits within the Anticholinergic / Antispasmodic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while oxybutynin has 6,440. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole blocks the enzyme that breaks down oxybutynin, which can cause the amount of oxybutynin in your body to double.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or oxybutynin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.