ketoconazole vs lansoprazole
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Side-by-side comparison of ketoconazole and lansoprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Lansoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
Nizoral
Prevacid
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Lansoprazole is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Lansoprazole can treat several conditions caused by too much stomach acid. It can heal duodenal and gastric ulcers. It also treats heartburn (GERD) and a damaged esophagus (erosive esophagitis).
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Lansoprazole works by blocking the enzyme in the stomach that produces acid. This helps to lower the amount of acid made. Lowering acid helps to heal damage and relieve symptoms.
No common side effects listed.
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Constipation
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
- Chronic Kidney Disease 32,775
- Acute Kidney Injury 18,670
- Renal Failure 13,811
- End Stage Renal Disease 9,782
- Renal Injury 9,520
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Lansoprazole may hide the symptoms of stomach cancer. If you have a poor response or early return of symptoms, your doctor may do more tests. Long-term use of PPIs like lansoprazole may increase your risk of bone fractures. It may also cause low magnesium levels or Vitamin B-12 deficiency.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
Talk to your doctor if you are pregnant or plan to become pregnant. Lansoprazole may affect bone development in the fetus. If you take lansoprazole with clarithromycin, also consider clarithromycin's pregnancy risks.
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How to Read This ketoconazole vs lansoprazole Comparison
ketoconazole is classified in the Azole Antifungal drug class, while lansoprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are available over the counter.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while lansoprazole has 84,558. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole needs stomach acid to dissolve and enter your body, but lansoprazole reduces the amount of acid your stomach makes.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ketoconazole or lansoprazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.