hydrochlorothiazide vs lithium
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Side-by-side comparison of hydrochlorothiazide and lithium. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor. It is recommended that serum lithium levels be monitored frequently if lisinopril is administered concomitantly with lithium.
Microzide
Lithobid, Eskalith
No summary available.
Lithium is a mood stabilizer medicine. It helps to balance mood swings.
Information not available.
Lithium is used to treat bipolar disorder. Bipolar disorder causes unusual shifts in mood, energy, activity levels, and concentration. Lithium helps to control the extreme highs (mania) and lows (depression) of this condition.
Information not available.
Lithium affects the flow of sodium in nerve and muscle cells in the body. This helps to stabilize your mood. It may also affect other chemical messenger systems in the brain.
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- • Tremor (shaking)
- • Nausea
- • Increased weight
- • Fatigue (feeling tired)
- • Vomiting
- Fatigue 10,014
- Nausea 9,709
- Diarrhoea 8,311
- Pain 7,663
- Dyspnoea 7,582
- Toxicity To Various Agents 2,179
- Drug Interaction 1,526
- Tremor 1,462
- Nausea 1,344
- Weight Increased 1,153
No specific warnings noted.
Lithium levels in your blood need to be monitored closely by your doctor. Too much lithium can be toxic and cause serious side effects. Make sure to attend all scheduled blood tests.
No pregnancy information available.
Lithium can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Lithium can pass into breast milk and may harm a nursing infant. Talk to your doctor about the best way to feed your baby if you are taking lithium.
How to Read This hydrochlorothiazide vs lithium Comparison
hydrochlorothiazide is classified in the Thiazide Diuretic drug class, while lithium sits within the Mood Stabilizer class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide has 43,279 submissions while lithium has 7,664. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs cause the body to lose sodium, which can make lithium build up to dangerous levels in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide or lithium.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.