hydrochlorothiazide/triamterene vs lithium
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Side-by-side comparison of hydrochlorothiazide/triamterene and lithium. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor. It is recommended that serum lithium levels be monitored frequently if lisinopril is administered concomitantly with lithium.
Dyazide, Maxzide
Lithobid, Eskalith
This medicine combines lisinopril and hydrochlorothiazide to lower high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Lithium is a mood stabilizer medicine. It helps to balance mood swings.
This medicine is used to treat high blood pressure. High blood pressure can lead to serious problems like stroke and heart attack if it is not treated. Lowering your blood pressure can help prevent these problems. You may need more than one medicine to control your blood pressure.
Lithium is used to treat bipolar disorder. Bipolar disorder causes unusual shifts in mood, energy, activity levels, and concentration. Lithium helps to control the extreme highs (mania) and lows (depression) of this condition.
Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water. This combination helps to lower blood pressure.
Lithium affects the flow of sodium in nerve and muscle cells in the body. This helps to stabilize your mood. It may also affect other chemical messenger systems in the brain.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Lightheadedness when standing up
- • Tremor (shaking)
- • Nausea
- • Increased weight
- • Fatigue (feeling tired)
- • Vomiting
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- General pain 7,665
- Difficulty breathing 7,584
- Toxicity To Various Agents 2,179
- Drug Interaction 1,526
- Tremor 1,462
- Nausea 1,344
- Weight Increased 1,153
This medicine can harm your unborn baby. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not take this medicine if you have ever had a severe allergic reaction (angioedema) to an ACE inhibitor or if you cannot urinate.
Lithium levels in your blood need to be monitored closely by your doctor. Too much lithium can be toxic and cause serious side effects. Make sure to attend all scheduled blood tests.
This medicine can cause harm or death to an unborn baby. Do not take this medicine if you are pregnant. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
Lithium can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Lithium can pass into breast milk and may harm a nursing infant. Talk to your doctor about the best way to feed your baby if you are taking lithium.
How to Read This hydrochlorothiazide/triamterene vs lithium Comparison
hydrochlorothiazide/triamterene is classified in the Thiazide / Potassium-Sparing Diuretic Combination drug class, while lithium sits within the Mood Stabilizer class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide/triamterene has 43,279 submissions while lithium has 7,664. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs cause the body to lose sodium, which makes it harder for the kidneys to remove lithium. this can lead to a dangerous buildup of lithium in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide/triamterene or lithium.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.