glycopyrrolate/formoterol vs tiotropium/olodaterol
Side-by-side comparison of glycopyrrolate/formoterol and tiotropium/olodaterol Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Bevespi Aerosphere
Stiolto Respimat
Bevespi Aerosphere is a medicine that helps people with COPD breathe easier. It contains two medicines that work together to open airways.
Stiolto Respimat combines two medicines to help you breathe better if you have COPD. It is used long-term to manage your COPD symptoms.
Bevespi Aerosphere is used to help manage chronic obstructive pulmonary disease (COPD). COPD is a long-term lung disease that makes it hard to breathe. This medicine helps to open your airways so you can breathe easier. It is not for sudden breathing problems.
Stiolto Respimat is used to treat chronic obstructive pulmonary disease (COPD). This includes chronic bronchitis and emphysema. This medicine helps you breathe better over a long period. Stiolto Respimat is not for sudden COPD symptoms or asthma.
This medicine combines two drugs: glycopyrrolate and formoterol. Glycopyrrolate is an anticholinergic that relaxes the muscles around your airways. Formoterol is a LABA that also relaxes airway muscles, helping you breathe better.
Stiolto Respimat contains two medicines that open your airways. Tiotropium helps to relax the muscles around your airways. Olodaterol is a long-acting beta-agonist (LABA) that also relaxes airway muscles.
- • Cough
- • Urinary tract infection
- • Common cold symptoms (nasopharyngitis)
- • Cough
- • Back pain
- Difficulty breathing 1,000
- Asthma 793
- Wheezing 674
- Cough 626
- Pneumonia 538
No adverse event reports.
LABA medicines like formoterol, when used alone for asthma, increase the risk of serious asthma problems. Bevespi Aerosphere is only for COPD, not asthma. Do not use Bevespi Aerosphere if you have asthma.
Using LABA medicines like Stiolto Respimat without a steroid medicine can be dangerous if you have asthma. Stiolto Respimat is not meant to treat asthma. Do not use Stiolto Respimat for sudden breathing problems. Using too much Stiolto Respimat can cause serious heart problems and may be fatal. If you have a bad reaction, like swelling or rash, stop using Stiolto Respimat and get medical help.
It is not known if Bevespi Aerosphere will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if this medicine passes into breast milk. Talk to your doctor about the best way to feed your baby if you are using Bevespi Aerosphere.
Tell your doctor if you are pregnant or plan to become pregnant. Stiolto Respimat should be used during pregnancy only if the benefit outweighs the risk to the baby. It is not known if Stiolto Respimat passes into breast milk.
Also Compare — Nearby Drugs
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How to Read This glycopyrrolate/formoterol vs tiotropium/olodaterol Comparison
glycopyrrolate/formoterol is classified in the LAMA / LABA Combination drug class, while tiotropium/olodaterol sits within the LAMA / LABA Combination class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, glycopyrrolate/formoterol has 3,631 submissions while tiotropium/olodaterol has 0. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between glycopyrrolate/formoterol and tiotropium/olodaterol — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.