galantamine vs rivastigmine
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of galantamine and rivastigmine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Razadyne
Exelon
Galantamine extended-release capsules help treat mild to moderate Alzheimer's disease. It can improve memory and thinking.
Rivastigmine (Exelon) is a medicine that helps improve memory and thinking in people with dementia. It works by increasing a chemical in the brain that is important for these functions.
This medicine treats mild to moderate Alzheimer's disease. Alzheimer's can affect memory, thinking, and behavior. Galantamine may help improve these symptoms.
This medicine treats mild to moderate dementia caused by Alzheimer's disease. It also treats mild to moderate dementia linked to Parkinson's disease. Dementia affects memory, thinking, and the ability to do daily activities.
Galantamine is a cholinesterase inhibitor. It works by increasing the amount of a certain chemical in the brain. This chemical helps nerve cells communicate better.
Rivastigmine helps increase the amount of a chemical called acetylcholine in your brain. Acetylcholine is important for memory and thinking. By increasing this chemical, rivastigmine can help improve these functions in people with dementia.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Nausea
- • Vomiting
- • Loss of appetite
- • Upset stomach
- • Weakness
- Fall 375
- Cognitive Disorder 306
- Constipation 291
- Balance Disorder 285
- Hypotension 285
- Death 2,177
- Fall 1,664
- Hallucination 1,365
- Confusional State 1,258
- Vomiting 885
Stop taking galantamine right away if you get a skin rash. This medicine can cause serious skin reactions. This medicine can also slow your heart rate or cause fainting.
This medicine can cause significant nausea, vomiting, diarrhea, loss of appetite, and weight loss. These side effects can lead to dehydration, which can be serious. If you have a skin reaction that spreads, stop taking this medicine.
It is not known if galantamine is safe to take during pregnancy. Animal studies suggest a risk to the fetus. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if galantamine passes into breast milk, so talk to your doctor if you are breastfeeding.
It is not known if rivastigmine will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if rivastigmine passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
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How to Read This galantamine vs rivastigmine Comparison
galantamine is classified in the Acetylcholinesterase Inhibitor drug class, while rivastigmine sits within the Acetylcholinesterase Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, galantamine has 1,542 submissions while rivastigmine has 7,349. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for galantamine or rivastigmine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.