furosemide vs leflunomide
Side-by-side comparison of furosemide and leflunomide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
In patients taking leflunomide, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.
Recommendation: Your doctor may need to monitor you more closely for side effects or adjust your dose of furosemide.
Lasix
Arava
Furosemide is a water pill (diuretic). It helps your body get rid of extra water and salt.
Leflunomide is a drug that can help reduce the symptoms of rheumatoid arthritis. It works by slowing down the body's immune system.
This medicine treats swelling (edema) from heart failure, liver problems, or kidney disease. It can also treat high blood pressure. Furosemide is helpful when you need a stronger diuretic.
Leflunomide treats active rheumatoid arthritis in adults. Rheumatoid arthritis is a disease that causes pain, swelling, and stiffness in the joints. This medicine can help reduce these symptoms.
Furosemide works in your kidneys. It helps your kidneys remove more salt and water from your blood. This lowers the amount of fluid in your body and lowers blood pressure.
Leflunomide is a pyrimidine synthesis inhibitor. This means it blocks a certain process in your body. By blocking this process, it can reduce inflammation and slow down the damage to your joints.
- • Dizziness
- • Headache
- • Blurred vision
- • Nausea
- • Vomiting
- • Diarrhea
- • Respiratory infection
- • Nausea
- • Headache
- • Rash
- Difficulty breathing 29,099
- Tiredness 20,389
- Diarrhea 19,940
- Feeling sick to your stomach 18,682
- Sudden kidney damage 18,530
- Rheumatoid arthritis 24,921
- Pain 20,055
- Joint pain 16,943
- Swollen joint 15,567
- Tiredness 15,384
Furosemide can cause you to lose too much fluid and electrolytes. This can lead to dehydration, low blood pressure, and kidney problems. Your doctor should check your blood regularly while you are taking this medicine.
This drug can cause serious harm to an unborn baby. If you are pregnant or could become pregnant, you should not take this medicine. This drug can also cause serious liver problems. If you have liver problems, you should not take this medicine. Your doctor will monitor your liver with blood tests.
Tell your doctor if you are pregnant or plan to become pregnant. Furosemide may not be safe during pregnancy. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
Do not take leflunomide if you are pregnant. It can cause birth defects. If you are breastfeeding, you should stop while taking this medicine.
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How to Read This furosemide vs leflunomide Comparison
furosemide is classified in the Loop Diuretic drug class, while leflunomide sits within the Disease-Modifying Antirheumatic Drug (DMARD) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, furosemide has 106,640 submissions while leflunomide has 92,870. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to leflunomide interferes with a protein that helps the body remove furosemide, which can cause the levels of furosemide in your blood to rise.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between furosemide and leflunomide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.