fluvoxamine vs sumatriptan
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Side-by-side comparison of fluvoxamine and sumatriptan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Sumatriptan: Rare postmarketing reports of weakness, hyperreflexia, and incoordination following use of an SSRI and sumatriptan. Sumatriptan - There have been rare postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of a selective serotonin reuptake inhibitor (SSRI) and sumatriptan. If concomitant treatment with sumatriptan and an SSRI (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Luvox
Imitrex
Fluvoxamine is a medicine that can help treat obsessive compulsive disorder (OCD). It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Sumatriptan injection is a medicine used to treat migraine and cluster headaches. It works by narrowing blood vessels in the brain.
Fluvoxamine is used to treat obsessive compulsive disorder (OCD). OCD involves having constant, unwanted thoughts or behaviors that you feel the need to repeat. These thoughts or actions can cause you distress and interfere with your daily life.
Sumatriptan injection is used to treat migraine headaches, with or without aura, in adults. It is also used to treat cluster headaches in adults. You should only use this medicine if you have a clear diagnosis of migraine or cluster headache. This medicine is not for preventing migraines or cluster headaches.
Fluvoxamine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluvoxamine can help reduce the symptoms of OCD.
Sumatriptan belongs to a class of drugs called triptans. It works by attaching to serotonin receptors in the brain. This causes blood vessels in the brain to narrow, which can relieve headache pain.
- • Abnormal ejaculation
- • Loss of appetite
- • Problems having an orgasm
- • Weakness
- • Diarrhea
- • Injection site reactions (pain, stinging, burning, swelling, bruising, bleeding)
- • Tingling
- • Dizziness
- • Warm or hot sensation
- • Burning sensation
- Drug Interaction 215
- Nausea 117
- Somnolence 114
- Anxiety 103
- Suicidal Ideation 96
- Headache 3,102
- Nausea 2,795
- Migraine 2,734
- Fatigue 2,100
- Pain 1,967
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Tell your doctor right away if you have any sudden changes in mood, behavior, thoughts, or feelings, especially if they are new, get worse, or worry you. Watch for suicidal thoughts or actions. Families and caregivers should also be aware of these risks.
Sumatriptan can cause serious heart problems, including heart attack and angina. If you have risk factors for heart disease (such as high blood pressure, high cholesterol, diabetes, smoking, or a family history of heart disease), your doctor should check your heart before you start taking this medicine. Sumatriptan can also cause stroke and other serious side effects. Call your doctor right away if you have chest pain, shortness of breath, weakness on one side of your body, or trouble speaking.
Tell your doctor if you are pregnant or plan to become pregnant. Fluvoxamine may cause problems for the baby if taken during pregnancy. Fluvoxamine can pass into breast milk and may harm a nursing baby.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. This medicine may harm your unborn baby. It is not known if this medicine passes into breast milk.
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How to Read This fluvoxamine vs sumatriptan Comparison
fluvoxamine is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while sumatriptan sits within the Triptan (Serotonin 5-HT1 Agonist) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluvoxamine has 645 submissions while sumatriptan has 12,698. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs affect serotonin levels in the brain, which can rarely lead to symptoms like muscle weakness or poor coordination.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluvoxamine or sumatriptan.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.