fluoxetine vs tramadol
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Side-by-side comparison of fluoxetine and tramadol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples Quinidine, fluoxetine, paroxetine and bupropion Inhibitors of CYP3A4 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP3A4 inhibitors can increase the plasma concentration of tramadol and may result in a greater amount of metabolism via CYP2D6 and greater levels of M1.
Prozac, Sarafem
Ultram, ConZip
Fluoxetine is a medicine that can help treat depression and other mental health conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Tramadol extended-release is a strong pain medicine. It is used to treat severe, ongoing pain that needs an opioid medicine when other pain medicines don't work well enough.
Fluoxetine can treat major depressive disorder in adults and children. It also treats obsessive-compulsive disorder (OCD) in adults and children. Fluoxetine can help with bulimia nervosa (an eating disorder) and panic disorder. Sometimes, it is used with another medicine called olanzapine to treat depression related to bipolar disorder.
Tramadol extended-release tablets are used to manage severe, long-lasting pain. This medicine is for pain that requires an opioid and cannot be treated well with other options. It is not for pain that comes and goes.
Fluoxetine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluoxetine can help improve mood and reduce symptoms of depression, OCD, and other conditions.
Tramadol works in your brain to change how your body feels pain. It binds to opioid receptors and also affects certain chemicals in the brain. This helps to lessen the pain you feel.
- • Abnormal dreams
- • Problems ejaculating
- • Loss of appetite
- • Feeling anxious
- • Feeling weak
- • Dizziness
- • Constipation
- • Feeling sick to your stomach
- • Headache
- • Feeling sleepy
- Drug Interaction 3,335
- Toxicity To Various Agents 3,316
- Nausea 3,233
- Fatigue 3,156
- Completed Suicide 2,904
- Dependence 7,820
- Overdose 3,855
- Vomiting 3,155
- Pain 2,876
- Nausea 2,712
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior. Fluoxetine is not approved for use in children younger than 7 years old.
Tramadol extended-release tablets can be habit-forming, leading to addiction, abuse, and misuse, which can result in overdose and death. Taking tramadol with other depressants like alcohol or benzodiazepines can cause very serious side effects, including slowed breathing, coma, and death. Even one dose of tramadol can be fatal, especially in children. Using tramadol for a long time during pregnancy can cause withdrawal symptoms in the newborn.
Talk to your doctor if you are pregnant or plan to become pregnant. Fluoxetine should only be used during pregnancy if the benefit outweighs the risk to the baby. Breastfeeding is not recommended while taking fluoxetine.
Tramadol may harm your unborn baby. Breastfeeding is not recommended while taking this medicine, as it can pass into breast milk and harm your baby.
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How to Read This fluoxetine vs tramadol Comparison
fluoxetine is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while tramadol sits within the Opioid Analgesic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluoxetine has 15,944 submissions while tramadol has 20,418. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluoxetine stops your body from breaking down tramadol normally. this can cause the drug to build up to higher levels in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluoxetine or tramadol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.