fluocinolone vs mometasone topical
Side-by-side comparison of fluocinolone and mometasone topical Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Synalar, Derma-Smoothe
Elocon
Fluocinolone is a topical steroid medicine. It helps reduce swelling, itching, and redness of the skin.
Mometasone Furoate Cream is a medicine that reduces skin inflammation and itching. It belongs to a class of drugs called topical corticosteroids.
This medicine treats skin problems that cause swelling and itching. It can help with conditions like eczema, dermatitis, and psoriasis. It works by reducing inflammation in the affected areas.
This cream treats skin problems that cause swelling, redness, and itching. These problems are called corticosteroid-responsive dermatoses. You can use this medicine if you are 2 years or older.
Fluocinolone is a corticosteroid. It works by reducing inflammation. This helps to relieve itching and other skin problems.
Mometasone Furoate Cream works by reducing inflammation in the skin. It does this by blocking certain substances in the body that cause swelling and itching. This helps to relieve the symptoms of skin conditions.
- • Burning
- • Itching
- • Irritation
- • Dryness
- • Burning
- • Itching
- • Skin thinning
No adverse event reports.
No adverse event reports.
If you get an infection, stop using bandages and talk to your doctor about treatment.
Using too much mometasone cream or using it for a long time can affect your hormone levels. This can cause problems like Cushing's syndrome or high blood sugar. Children are more likely to get these side effects. This medicine may also increase your risk of cataracts and glaucoma. Tell your doctor if you have blurred vision.
Tell your doctor if you are pregnant or breastfeeding before using this medicine. It is not known if fluocinolone can harm an unborn baby or pass into breast milk.
If you are pregnant, only use this cream if your doctor says it is okay. It is not known if this medicine passes into breast milk. Talk to your doctor before using it if you are breastfeeding.
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How to Read This fluocinolone vs mometasone topical Comparison
fluocinolone is classified in the Topical Corticosteroid drug class, while mometasone topical sits within the Topical Corticosteroid class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluocinolone has 0 submissions while mometasone topical has 0. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluocinolone and mometasone topical — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.