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betamethasone vs mometasone topical

Side-by-side comparison of betamethasone and mometasone topical Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

Drug Class
betamethasone Topical Corticosteroid
mometasone topical Topical Corticosteroid
Type
betamethasone Prescription
mometasone topical Prescription
Summary
betamethasone

Betamethasone dipropionate cream is a strong steroid medicine used on the skin. It helps reduce swelling, itching, and redness.

mometasone topical

Mometasone Furoate Cream is a medicine that reduces skin inflammation and itching. It belongs to a class of drugs called topical corticosteroids.

What It Treats
betamethasone

This cream treats skin problems that cause swelling, itching, and redness. These problems are called corticosteroid-responsive dermatoses. It is for use in people ages 13 and older.

mometasone topical

This cream treats skin problems that cause swelling, redness, and itching. These problems are called corticosteroid-responsive dermatoses. You can use this medicine if you are 2 years or older.

How It Works
betamethasone

Betamethasone is a type of steroid. It works by reducing inflammation in the skin. This helps to relieve itching and other symptoms.

mometasone topical

Mometasone Furoate Cream works by reducing inflammation in the skin. It does this by blocking certain substances in the body that cause swelling and itching. This helps to relieve the symptoms of skin conditions.

Common Side Effects
betamethasone
  • Stinging (in adults)
  • Skin getting thinner (in children)
  • Spider veins (in children)
  • Bruising (in children)
  • Shiny skin (in children)
mometasone topical
  • Burning
  • Itching
  • Skin thinning
FAERS Reports
betamethasone

No adverse event reports.

mometasone topical

No adverse event reports.

Serious Warnings
betamethasone

This medicine can affect your hormone system. It may cause your body to make less of its own natural steroids. Using too much, using it for too long, or covering large areas of skin can increase this risk. This medicine may also increase your risk of cataracts and glaucoma. Tell your doctor if you have blurred vision or other vision problems.

mometasone topical

Using too much mometasone cream or using it for a long time can affect your hormone levels. This can cause problems like Cushing's syndrome or high blood sugar. Children are more likely to get these side effects. This medicine may also increase your risk of cataracts and glaucoma. Tell your doctor if you have blurred vision.

Pregnancy
betamethasone

Tell your doctor if you are pregnant or plan to become pregnant. Using large amounts of this medicine during pregnancy may increase the risk of having a low birth weight baby. Talk to your doctor if you are breastfeeding. Use on the smallest area of skin and for the shortest time needed.

mometasone topical

If you are pregnant, only use this cream if your doctor says it is okay. It is not known if this medicine passes into breast milk. Talk to your doctor before using it if you are breastfeeding.

Also Compare — Nearby Drugs

How to Read This betamethasone vs mometasone topical Comparison

betamethasone is classified in the Topical Corticosteroid drug class, while mometasone topical sits within the Topical Corticosteroid class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, betamethasone has 0 submissions while mometasone topical has 0. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between betamethasone and mometasone topical — always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.