ezetimibe/simvastatin vs ketoconazole
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Side-by-side comparison of ezetimibe/simvastatin and ketoconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.
Vytorin
Nizoral
Vytorin is a combination medicine that contains ezetimibe and simvastatin. It helps lower bad cholesterol (LDL-C) in your blood.
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Vytorin is used along with a healthy diet to lower high LDL cholesterol. It is used in adults with primary hyperlipidemia and in adults and children 10 years and older with heterozygous familial hypercholesterolemia (HeFH). Vytorin can also be used with other cholesterol-lowering treatments for adults with homozygous familial hypercholesterolemia (HoFH). Simvastatin, one of the drugs in Vytorin, can also lower the risk of heart problems like heart attack and stroke in adults with heart disease, blood vessel disease, or diabetes.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Ezetimibe reduces the amount of cholesterol your body absorbs from food. Simvastatin belongs to a class of drugs called statins. Statins lower cholesterol by blocking a substance your body needs to make cholesterol.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
- • Headache
- • Increased liver enzyme (ALT)
- • Muscle pain
- • Upper respiratory tract infection
- • Diarrhea
No common side effects listed.
- Feeling sick to your stomach 1,008
- Feeling tired 771
- Feeling lightheaded 731
- General pain 702
- Muscle pain 669
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
Vytorin can cause muscle problems, including myopathy and rhabdomyolysis. Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel sick. Vytorin can also cause liver problems. Your doctor may do blood tests to check your liver before you start taking Vytorin and while you take it.
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Do not take Vytorin if you are pregnant. It can harm your unborn baby. Talk to your doctor if you are breastfeeding or plan to breastfeed, as it is not recommended during treatment with Vytorin.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
Also Compare, Nearby Drugs
Compare ketoconazole with
How to Read This ezetimibe/simvastatin vs ketoconazole Comparison
ezetimibe/simvastatin is classified in the Cholesterol Absorption Inhibitor / Statin Combination drug class, while ketoconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ezetimibe/simvastatin has 3,881 submissions while ketoconazole has 4,227. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole stops the body from breaking down the simvastatin in your medicine. this can cause the drug to reach high levels in your blood, which may damage your muscles.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ezetimibe/simvastatin or ketoconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.