erythromycin vs simvastatin

According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.

Side-by-side comparison of erythromycin and simvastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

Examples: Select azole anti-fungals (e.g., itraconazole, ketoconazole, posaconazole, and voriconazole), select macrolide antibiotics (e.g., erythromycin and clarithromycin, telithromycin), select HIV protease inhibitors (e.g., nelfinavir, ritonavir, and darunavir/ritonavir), select HCV protease inhibitors (e.g., boceprevir and telaprevir), cobicistat-containing products, and nefazodone.

Drug Class
erythromycin Macrolide Antibiotic
simvastatin HMG-CoA Reductase Inhibitor (Statin)
Type
erythromycin Prescription
simvastatin Prescription
Summary
erythromycin

Erythromycin Topical Solution is a medicine that you put on your skin to treat acne. It contains an antibiotic to help clear up your skin.

simvastatin

No summary available.

What It Treats
erythromycin

Erythromycin Topical Solution treats acne vulgaris. This medicine helps to reduce acne on your face, neck, shoulders, chest, and back. It works by fighting the bacteria that cause acne.

simvastatin

Information not available.

How It Works
erythromycin

Erythromycin is a macrolide antibiotic. It works by stopping the growth of bacteria. This helps to reduce inflammation and clear up acne.

simvastatin

Information not available.

Common Side Effects
erythromycin
  • Peeling
  • Dryness
  • Itching
  • Redness
  • Oily skin
simvastatin
  • Headache
  • Upper respiratory tract infection
  • Muscle pain
  • Diarrhea
FAERS Reports
erythromycin
  • Drug Hypersensitivity 4,088
  • Nausea 1,271
  • Vomiting 1,121
  • Diarrhoea 1,069
  • Dyspnoea 1,023
simvastatin
  • Fatigue 13,574
  • Nausea 12,945
  • Dyspnoea 12,431
  • Diarrhoea 11,813
  • Dizziness 10,971
Serious Warnings
erythromycin

You should not use this medicine if you are allergic to any of its ingredients.

simvastatin

No specific warnings noted.

Pregnancy
erythromycin

It is not known if erythromycin topical solution can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding.

simvastatin

No pregnancy information available.

Also Compare, Nearby Drugs

How to Read This erythromycin vs simvastatin Comparison

erythromycin is classified in the Macrolide Antibiotic drug class, while simvastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, erythromycin has 8,572 submissions while simvastatin has 61,734. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to erythromycin interferes with the way your body clears simvastatin, which can lead to a buildup of the medication in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for erythromycin or simvastatin.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.