erythromycin vs repaglinide
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of erythromycin and repaglinide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Drugs that are known to inhibit CYP3A4 include antifungal agents (ketoconazole, itraconazole) and antibacterial agents (clarithromycin, erythromycin).
E-Mycin, Ery-Tab
Prandin
Erythromycin Topical Solution is a medicine that you put on your skin to treat acne. It contains an antibiotic to help clear up your skin.
Repaglinide (Prandin) helps control blood sugar in adults with type 2 diabetes. It works best when used with diet and exercise.
Erythromycin Topical Solution treats acne vulgaris. This medicine helps to reduce acne on your face, neck, shoulders, chest, and back. It works by fighting the bacteria that cause acne.
Repaglinide is used to lower blood sugar in adults with type 2 diabetes. It should be used along with a healthy diet and regular exercise. This medicine is not for people with type 1 diabetes or diabetic ketoacidosis.
Erythromycin is a macrolide antibiotic. It works by stopping the growth of bacteria. This helps to reduce inflammation and clear up acne.
Repaglinide helps your pancreas release insulin after you eat. Insulin helps move sugar from your blood into your cells. This lowers your blood sugar levels.
- • Peeling
- • Dryness
- • Itching
- • Redness
- • Oily skin
- • Low blood sugar
- • Upper respiratory infection
- • Headache
- • Sinus infection
- • Joint pain
- Drug Hypersensitivity 4,088
- Nausea 1,271
- Vomiting 1,121
- Diarrhoea 1,069
- Dyspnoea 1,023
- Hypoglycaemia 765
- Acute Kidney Injury 548
- Drug Interaction 418
- Diarrhoea 365
- Lactic Acidosis 364
You should not use this medicine if you are allergic to any of its ingredients.
Repaglinide can cause low blood sugar (hypoglycemia). If you skip a meal, skip your dose of repaglinide to avoid low blood sugar. Do not use repaglinide with NPH-insulin. There is no proof that repaglinide lowers your risk of heart problems.
It is not known if erythromycin topical solution can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Poorly controlled diabetes during pregnancy can harm both the mother and the baby. Repaglinide is not recommended while breastfeeding due to the risk of low blood sugar in the baby.
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How to Read This erythromycin vs repaglinide Comparison
erythromycin is classified in the Macrolide Antibiotic drug class, while repaglinide sits within the Meglitinide class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, erythromycin has 8,572 submissions while repaglinide has 2,460. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to erythromycin blocks the enzyme that breaks down repaglinide, which can cause the drug to build up in your body. this may cause your blood sugar to drop too low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for erythromycin or repaglinide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.