efavirenz/emtricitabine/tenofovir vs famotidine
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Side-by-side comparison of efavirenz/emtricitabine/tenofovir and famotidine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.5 Drugs Without Clinically Significant Interactions with Efavirenz No dosage adjustment is recommended when efavirenz is given with the following: aluminum/magnesium hydroxide antacids, azithromycin, cetirizine, famotidine, fluconazole, lorazepam, nelfinavir, nucleoside reverse transcriptase inhibitors (abacavir, emtricitabine, lamivudine, stavudine, tenofovir disoproxil fumarate, zidovudine), paroxetine, and raltegravir.
Pepcid
Efavirenz is a drug used to treat HIV-1 infection. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTI).
Famotidine (Pepcid) reduces stomach acid. It is used to treat ulcers, heartburn, and acid reflux.
Efavirenz is used to treat HIV-1, the virus that causes AIDS. It helps to lower the amount of virus in your body. This medicine must be used with other HIV medicines.
This medicine treats active duodenal ulcers and active gastric ulcers. It also treats heartburn (nonerosive GERD) and erosive esophagitis (damage to the esophagus from acid reflux). Famotidine can also treat conditions where the stomach makes too much acid, like Zollinger-Ellison syndrome. It can also lower the risk of duodenal ulcers coming back.
Efavirenz blocks an enzyme called reverse transcriptase. HIV needs this enzyme to make copies of itself. By blocking it, efavirenz helps to slow down the spread of HIV in your body.
Famotidine is an H2 receptor antagonist. This means it blocks histamine, a substance that tells your stomach to make acid. By blocking histamine, famotidine reduces the amount of acid your stomach produces.
- • Rash
- • Dizziness
- • Nausea
- • Headache
- • Fatigue
- • Headache
- • Dizziness
- • Constipation
- • Diarrhea
- Virologic Failure 952
- Drug Interaction 748
- Drug Resistance 735
- Viral Mutation Identified 674
- Pathogen Resistance 623
- Nausea 7,258
- Fatigue 6,866
- Chronic Kidney Disease 6,644
- Diarrhoea 6,452
- Dyspnoea 5,202
Efavirenz can cause serious side effects, including psychiatric problems like depression or suicidal thoughts. Tell your doctor right away if you have any of these symptoms. Efavirenz can also harm your liver. Your doctor should check your liver function before and during treatment. Do not take efavirenz by itself.
In elderly patients and those with kidney problems, famotidine can cause confusion, delirium, or hallucinations. If you are elderly or have kidney problems, your doctor may prescribe a lower dose. Famotidine can hide the symptoms of stomach cancer. If your symptoms don't improve, tell your doctor.
Efavirenz can harm your unborn baby, especially during the first 3 months of pregnancy. Talk to your doctor about using birth control while taking this medicine. Breastfeeding is not recommended while taking efavirenz.
It is not known if famotidine will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Famotidine may pass into breast milk, but it's not expected to harm the baby. Talk to your doctor about breastfeeding while taking this medicine.
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How to Read This efavirenz/emtricitabine/tenofovir vs famotidine Comparison
efavirenz/emtricitabine/tenofovir is classified in the NNRTI / NRTI Combination drug class, while famotidine sits within the H2 Receptor Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, efavirenz/emtricitabine/tenofovir has 3,732 submissions while famotidine has 32,422. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two medicines do not have a meaningful effect on each other when taken at the same time.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for efavirenz/emtricitabine/tenofovir or famotidine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.