drospirenone/ethinyl estradiol vs lamotrigine
Side-by-side comparison of drospirenone/ethinyl estradiol and lamotrigine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation. This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary.
Recommendation: Your doctor may need to increase your dose of lamotrigine to ensure it still works correctly.
Yaz, Yasmin
Lamictal
This medicine contains drospirenone and ethinyl estradiol, which are hormones that prevent pregnancy. It also contains folate to help raise folate levels.
Lamotrigine is a medicine that can treat seizures and bipolar disorder. It works by reducing irregular electrical activity in the brain.
This medicine can prevent pregnancy. It can also treat symptoms of premenstrual dysphoric disorder (PMDD) if you also want birth control. This medicine can also treat moderate acne in women at least 14 years old who also want birth control.
Lamotrigine can treat epilepsy in adults and children 2 years and older. It can help with partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome. It can also be used to delay mood episodes in adults with bipolar I disorder.
This medicine prevents pregnancy by stopping ovulation (the release of an egg from the ovary). It also changes the lining of the uterus, making it harder for a fertilized egg to implant. The folate helps increase folate levels in the body.
Lamotrigine affects how nerves in the brain send signals to each other. It is thought to work by decreasing the release of certain chemicals. This helps to stabilize electrical activity and prevent seizures or mood swings.
- • Headache or migraine
- • Irregular periods
- • Nausea or vomiting
- • Breast pain or tenderness
- • Dizziness
- • Headache
- • Double vision
- • Uncoordinated movements
- • Nausea
- Pain 13,037
- Injury 10,860
- Blood clot in the lungs 9,316
- Blood clot in a deep vein 8,390
- Anxiety 6,996
- Skin rash 8,408
- Seizure 6,527
- Feeling sick to your stomach 6,151
- Tiredness 5,914
- Feeling lightheaded 5,771
Cigarette smoking increases your risk of serious heart problems when using birth control pills. This risk is higher if you are over 35 and smoke. Women over 35 who smoke should not use this medicine.
Lamotrigine can cause a serious skin rash that may require you to go to the hospital. This rash can be life-threatening. The risk is higher in children. Stop taking lamotrigine and see a doctor right away if you get a rash, fever, or swollen lymph nodes.
Do not use this medicine if you are pregnant. This medicine can reduce milk production while breastfeeding. If possible, use other birth control methods until you stop breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Lamotrigine may cause harm to an unborn baby. There is a pregnancy registry for women who take lamotrigine during pregnancy. You can enroll by calling 1-888-233-2334.
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How to Read This drospirenone/ethinyl estradiol vs lamotrigine Comparison
drospirenone/ethinyl estradiol is classified in the Combined Oral Contraceptive drug class, while lamotrigine sits within the Anticonvulsant class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, drospirenone/ethinyl estradiol has 48,599 submissions while lamotrigine has 32,771. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to the birth control pill makes your body get rid of lamotrigine much faster than usual. this can lower the amount of medicine in your blood and make it less effective at preventing seizures.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between drospirenone/ethinyl estradiol and lamotrigine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.