diltiazem vs nebivolol
Side-by-side comparison of diltiazem and nebivolol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.3 ) Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate, blood pressure, and cardiac contractility. 7.4 Calcium Channel Blockers Nebivolol can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide.
Recommendation: Your doctor should closely monitor your heart rate and blood pressure while you are taking this combination.
Diltiazem is a medicine that helps lower high blood pressure and prevent chest pain. It belongs to a class of drugs called calcium channel blockers.
Nebivolol is a medicine that lowers high blood pressure. Lowering blood pressure helps prevent strokes and heart attacks.
Diltiazem is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. Diltiazem also helps manage chronic stable angina (chest pain) and angina caused by spasms in the heart's blood vessels.
Nebivolol treats high blood pressure. High blood pressure increases your risk of heart attack and stroke. Nebivolol can be used alone or with other blood pressure medicines.
Diltiazem works by relaxing blood vessels, which lowers blood pressure. It also reduces the heart's workload, which can prevent chest pain. This medicine blocks calcium from entering heart and blood vessel cells.
Nebivolol is a beta-blocker that mainly affects the heart. It works by relaxing blood vessels and slowing down your heart rate. This makes it easier for your heart to pump blood and lowers blood pressure.
- • Swelling in your ankles or feet
- • Headache
- • Dizziness
- • Slow heart rate
- • Constipation
- • Headache
- • Tiredness
- • Dizziness
- • Diarrhea
- • Nausea
- Shortness of breath 3,200
- Tiredness 2,637
- Feeling sick to your stomach 2,372
- Discomfort 2,364
- Feeling lightheaded 2,089
- Sudden kidney damage 922
- Difficulty breathing 773
- Diarrhea 724
- Interaction with another medicine 616
- Low blood pressure 610
Diltiazem can interact with other heart medications. Tell your doctor if you take beta-blockers or digoxin. Using diltiazem with these drugs can cause heart problems. Your doctor may need to adjust your dosages.
Do not stop taking nebivolol suddenly if you have heart disease. This can make chest pain worse or cause a heart attack. Talk to your doctor before stopping nebivolol. They will likely lower your dose slowly over 1 to 2 weeks.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if diltiazem will harm your unborn baby. Diltiazem passes into breast milk, so talk to your doctor about breastfeeding while taking this medicine.
Talk to your doctor if you are pregnant or plan to become pregnant. Nebivolol may cause problems for the baby, such as low blood pressure or slow heart rate. Breastfeeding is not recommended while taking nebivolol.
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How to Read This diltiazem vs nebivolol Comparison
diltiazem is classified in the Calcium Channel Blocker drug class, while nebivolol sits within the Beta-1 Selective Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diltiazem has 12,662 submissions while nebivolol has 3,645. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these medicines slow the heart rate and lower blood pressure. using them together can cause your heart to beat too slowly or weaken its pumping strength.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between diltiazem and nebivolol - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.