digoxin vs ibuprofen
Side-by-side comparison of digoxin and ibuprofen. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.
Recommendation: Your doctor should check your digoxin levels before you begin taking ibuprofen and monitor you for side effects.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Ibuprofen is a drug that can reduce pain and fever. It belongs to a class of drugs called NSAIDs.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Ibuprofen can help with minor aches and pains. You can use it for headaches, toothaches, backaches, menstrual cramps, and muscle aches. It can also help with the common cold, minor arthritis pain, and fever.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Ibuprofen works by reducing hormones that cause pain and swelling in the body. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain signals.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Nausea
- • Headache
- • Diarrhea
- • Vomiting
- • Dizziness
- Shortness of breath 6,062
- Feeling sick to your stomach 4,747
- Feeling lightheaded or unsteady 4,442
- Feeling very tired 4,174
- Irregular heartbeat 3,972
- Pain 18,851
- Tiredness 17,869
- Feeling sick to your stomach 17,349
- Headache 15,814
- Joint pain 12,952
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
NSAIDs like ibuprofen may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. NSAIDs also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Ask a doctor before using if you are pregnant or breastfeeding. NSAIDs like ibuprofen may cause harm to the fetus.
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How to Read This digoxin vs ibuprofen Comparison
digoxin is classified in the Cardiac Glycoside drug class, while ibuprofen sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,397 submissions while ibuprofen has 82,835. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ibuprofen can lead to higher levels of digoxin in your bloodstream. this could increase the risk of side effects from the digoxin.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between digoxin and ibuprofen - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.