diflunisal vs hydrochlorothiazide
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Side-by-side comparison of diflunisal and hydrochlorothiazide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
In normal volunteers, concomitant administration of diflunisal and hydrochlorothiazide resulted in significantly increased plasma levels of hydrochlorothiazide. Diflunisal decreased the hyperuricemic effect of hydrochlorothiazide.
Dolobid
Microzide
Diflunisal is a medicine that can help with pain and swelling. It belongs to a class of drugs called NSAIDs.
No summary available.
Diflunisal can help with mild to moderate pain. It can also treat the symptoms of osteoarthritis and rheumatoid arthritis. You should use the lowest dose that works for you, for the shortest time needed.
Information not available.
Diflunisal reduces pain and swelling by blocking the production of certain chemicals in your body. These chemicals cause inflammation and pain. By blocking them, diflunisal helps to relieve your symptoms.
Information not available.
- • Nausea
- • Vomiting
- • Upset stomach
- • Stomach pain
- • Diarrhea
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- Nausea 66
- Fatigue 57
- Pain 50
- Drug Hypersensitivity 47
- Headache 45
- Fatigue 10,014
- Nausea 9,709
- Diarrhoea 8,311
- Pain 7,663
- Dyspnoea 7,582
NSAIDs like diflunisal can increase your risk of heart problems like heart attack and stroke, which can be deadly. This risk is higher if you take it for a long time. You should not take diflunisal if you are having heart bypass surgery. NSAIDs also raise your risk of serious stomach problems like bleeding and ulcers, which can also be deadly. Older adults are at higher risk for these stomach problems.
No specific warnings noted.
Tell your doctor if you are pregnant or plan to become pregnant. Taking diflunisal late in pregnancy may harm your baby. It is not known if diflunisal passes into breast milk, so talk to your doctor before breastfeeding.
No pregnancy information available.
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How to Read This diflunisal vs hydrochlorothiazide Comparison
diflunisal is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while hydrochlorothiazide sits within the Thiazide Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diflunisal has 265 submissions while hydrochlorothiazide has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to diflunisal causes the body to keep more of the water pill in the blood, which might make the water pill stronger. it also changes how the water pill affects certain chemicals like uric acid in the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diflunisal or hydrochlorothiazide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.