deutetrabenazine vs paroxetine
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Side-by-side comparison of deutetrabenazine and paroxetine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Concomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Austedo
Paxil
Austedo and Austedo XR help control movements in adults with Huntington's disease or tardive dyskinesia. It works by changing the levels of certain chemicals in the brain.
Paroxetine (Paxil) is a medicine that can help treat depression and anxiety disorders. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Austedo and Austedo XR are used to treat chorea (uncontrollable movements) caused by Huntington's disease. They also treat tardive dyskinesia, which causes repetitive, involuntary movements. These medicines can help you control these movements.
Paroxetine is used to treat several conditions in adults. These include major depressive disorder (MDD), obsessive compulsive disorder (OCD), panic disorder (PD), social anxiety disorder (SAD), generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD). It helps to improve mood and reduce anxiety and panic feelings.
Austedo and Austedo XR affect a protein in the brain called VMAT2. This protein helps move certain chemicals like dopamine. By blocking VMAT2, Austedo and Austedo XR help regulate these chemicals, which reduces unwanted movements.
Paroxetine works by increasing the amount of serotonin in your brain. Serotonin is a natural substance that helps regulate mood. By increasing serotonin levels, paroxetine can help improve symptoms of depression and anxiety.
- • Feeling sleepy
- • Diarrhea
- • Dry mouth
- • Feeling tired
- • Runny nose
- • Abnormal ejaculation
- • Weakness or fatigue
- • Constipation
- • Decreased appetite
- • Diarrhea
- Depression 463
- Dyskinesia 403
- Death 402
- Tremor 330
- Somnolence 305
- Drug Interaction 1,825
- Fatigue 1,821
- Nausea 1,738
- Toxicity To Various Agents 1,579
- Anxiety 1,476
Austedo and Austedo XR can increase the risk of depression and suicidal thoughts in people with Huntington's disease. If you have Huntington's disease, your doctor will monitor you closely for any changes in your mood or behavior. Tell your doctor right away if you feel depressed or have thoughts of harming yourself. You should not take Austedo or Austedo XR if you are suicidal or have untreated depression.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor will monitor you closely for worsening depression or suicidal thoughts. Paroxetine is not approved for use in children.
It is not known if Austedo or Austedo XR will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Austedo or Austedo XR passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
Paroxetine may cause harm to your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Taking paroxetine later in pregnancy may cause problems for the newborn.
Also Compare, Nearby Drugs
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How to Read This deutetrabenazine vs paroxetine Comparison
deutetrabenazine is classified in the VMAT2 Inhibitor drug class, while paroxetine sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, deutetrabenazine has 1,903 submissions while paroxetine has 8,439. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to paroxetine stops the body from breaking down deutetrabenazine properly. this causes the medicine to build up to higher levels in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for deutetrabenazine or paroxetine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.