desipramine vs propafenone
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Side-by-side comparison of desipramine and propafenone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
(7.6) 7.1 CYP2D6 and CYP3A4 Inhibitors Drugs that inhibit CYP2D6 (such as desipramine, paroxetine, ritonavir, sertraline) and CYP3A4 (such as ketoconazole, ritonavir, saquinavir, erythromycin, grapefruit juice) can be expected to cause increased plasma levels of propafenone.
Norpramin
Rythmol
Desipramine is a medicine used to treat depression. It belongs to a class of drugs called tricyclic antidepressants.
Propafenone (Rythmol) is a medicine that helps control irregular heartbeats. It works by slowing down electrical signals in the heart.
Desipramine is used to treat depression. Depression can cause feelings of sadness, loss of interest, and trouble functioning in daily life. This medicine can help improve your mood and overall well-being.
This medicine is used to help keep your heart rhythm normal if you have atrial fibrillation or supraventricular tachycardia. These are types of fast or irregular heartbeats that can cause problems. It can also treat life-threatening ventricular arrhythmias. Propafenone is for people without structural heart disease.
Desipramine works by affecting certain chemicals in the brain. It helps to increase the levels of norepinephrine. This can improve mood and reduce symptoms of depression.
Propafenone works by affecting the electrical activity in your heart. It slows down the signals that cause irregular heartbeats. This helps your heart beat more regularly.
- • Drowsiness
- • Dizziness
- • Dry mouth
- • Constipation
- • Blurred vision
- • Unusual taste
- • Nausea
- • Vomiting
- • Dizziness
- • Constipation
- Fatigue 119
- Completed Suicide 116
- Nausea 77
- Headache 70
- Weight Increased 68
- Atrial Fibrillation 347
- Drug Interaction 320
- Dizziness 262
- Toxicity To Various Agents 231
- Dyspnoea 226
Antidepressants may increase the risk of suicidal thoughts or actions in children, teens, and young adults. Watch for worsening depression, unusual behavior, or thoughts of suicide. Desipramine is not approved for use in children.
This medicine may increase the risk of death in people with heart problems. Do not take this medicine if you have structural heart disease and non-life-threatening ventricular arrhythmias. Talk to your doctor about the risks and benefits of taking this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. Desipramine may affect your baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. This medicine can cross the placenta, and may affect the baby. Your doctor will monitor you and your baby for any problems.
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How to Read This desipramine vs propafenone Comparison
desipramine is classified in the Tricyclic Antidepressant (TCA) drug class, while propafenone sits within the Class IC Antiarrhythmic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, desipramine has 450 submissions while propafenone has 1,386. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to desipramine blocks the enzymes that usually break down propafenone, which can increase the amount of medicine in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for desipramine or propafenone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.