darunavir vs nifedipine
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of darunavir and nifedipine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Calcium Channel Blockers : amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blockers Clinical monitoring of patients is recommended.
Prezista
Procardia, Adalat
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Nifedipine is a calcium channel blocker. It helps to relax blood vessels, which can lower blood pressure and reduce chest pain.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
This medicine treats chest pain (angina) caused by tight blood vessels. It also treats high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Nifedipine blocks calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels. As a result, the heart doesn't have to work as hard, and blood pressure goes down.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Swelling, especially in the legs or ankles
- • Headache
- • Fatigue
- • Dizziness
- • Constipation
- Foetal Exposure During Pregnancy 1,150
- Drug Interaction 981
- Pain 889
- Emotional Distress 812
- Anxiety 811
- Dyspnoea 2,429
- Fatigue 2,304
- Diarrhoea 2,264
- Nausea 2,220
- Headache 1,997
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
In rare cases, nifedipine can cause serious gastrointestinal problems, including obstruction. If you experience severe abdominal pain, vomiting, or inability to pass stool, seek immediate medical attention.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if nifedipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
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How to Read This darunavir vs nifedipine Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while nifedipine sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while nifedipine has 11,214. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to darunavir slows down how the body breaks down nifedipine, which can lead to higher levels of the heart medicine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for darunavir or nifedipine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.