dapsone topical vs trimethoprim
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Side-by-side comparison of dapsone topical and trimethoprim. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Trimethoprim/sulfamethoxazole (TMP/SMX) increases the systemic level of dapsone and its metabolites ( 7.1 ). 7.1 Trimethoprim-Sulfamethoxazole A drug-drug interaction study evaluated the effect of the use of dapsone gel, 5% in combination with double strength (160 mg/800 mg) trimethoprim-sulfamethoxazole (TMP/SMX).
Aczone
Primsol
Aczone Gel is a topical medicine used to treat acne. It helps reduce inflammation and kill bacteria that cause acne.
This medicine contains sulfamethoxazole and trimethoprim. It is an antibiotic that fights bacteria in your body.
Aczone Gel is used to treat acne in people ages 9 and older. It helps to clear up pimples and prevent new ones from forming. Use it as directed by your doctor.
This medicine can treat urinary tract infections, ear infections in children, and bronchitis in adults. It also treats shigellosis, a type of diarrhea. It can also treat or prevent Pneumocystis jiroveci pneumonia, and treat traveler's diarrhea.
Aczone Gel contains dapsone, which is a type of anti-inflammatory medicine. It works by reducing swelling and redness. It also kills certain bacteria that can cause acne.
This medicine works by stopping bacteria from making folic acid. Bacteria need folic acid to grow and multiply. By blocking folic acid production, the medicine kills the bacteria.
- • Dryness where you put the gel
- • Itching where you put the gel
- • Nausea
- • Vomiting
- • Loss of appetite
- • Skin rash
- • Hives
No adverse event reports.
- Nausea 945
- Diarrhoea 848
- Headache 835
- Malaise 816
- Pyrexia 721
Aczone Gel can cause a rare but serious condition called methemoglobinemia. If your skin turns bluish or grey, stop using Aczone Gel and get medical help right away. If you have a G6PD deficiency, talk to your doctor before using this medicine. It may cause blood problems.
Rarely, sulfonamide drugs like this one have caused severe reactions. These include Stevens-Johnson syndrome, toxic epidermal necrolysis, liver damage, and blood problems. Tell your doctor right away if you have a fever, rash, blisters, mouth sores, or signs of infection.
It is not known if Aczone Gel can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if Aczone Gel passes into breast milk. Talk to your doctor before breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. This medicine may not be safe for your baby. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
How to Read This dapsone topical vs trimethoprim Comparison
dapsone topical is classified in the Topical Anti-Inflammatory drug class, while trimethoprim sits within the Dihydrofolate Reductase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dapsone topical has 0 submissions while trimethoprim has 4,165. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to trimethoprim can cause dapsone to build up in your body by slowing down how it is cleared out.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for dapsone topical or trimethoprim.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.