cyclosporine vs octreotide
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of cyclosporine and octreotide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS The following drugs require monitoring and possible dose adjustment when used with octreotide acetate injection : cyclosporine, insulin, oral hypoglycemic agents, beta-blockers, and bromocriptine. ( 7.6 ) 7.1 Cyclosporine Octreotide has been associated with alterations in nutrient absorption, so it may have an effect on absorption of orally administered drugs. Concomitant administration of octreotide acetate injection with cyclosporine may decrease blood levels of cyclosporine and result in transplant rejection.
Neoral, Sandimmune, Restasis
Sandostatin
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Octreotide is a drug that mimics a natural hormone in your body. It is used to treat certain conditions caused by too much of certain hormones.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Octreotide is used to lower growth hormone and insulin-like growth factor-1 in people with acromegaly who haven't responded to other treatments. It also helps manage severe diarrhea and flushing caused by carcinoid tumors. Additionally, it can treat watery diarrhea caused by VIPomas (tumors that release vasoactive intestinal peptide).
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
This medicine works by mimicking somatostatin, a natural hormone in your body. It reduces the amount of certain hormones, like growth hormone, that your body makes. By doing this, it helps control the symptoms caused by having too much of these hormones.
- • Irritation where the drops are applied (8%)
- • Gallbladder problems
- • Slow heart rate
- • Diarrhea
- • Loose stools
- • Nausea
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
- Diarrhoea 526
- Death 375
- Nausea 345
- Fatigue 305
- Malignant Neoplasm Progression 235
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Octreotide can cause heart problems, including a higher risk of certain types of heart block. Your doctor may monitor your heart if you receive this drug intravenously. It can also cause gallbladder problems, high or low blood sugar, and thyroid issues. Tell your doctor right away if you notice new or worsening symptoms.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
There is limited information about the safety of octreotide during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if octreotide passes into breast milk, so talk to your doctor about breastfeeding while using this medicine.
How to Read This cyclosporine vs octreotide Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while octreotide sits within the Somatostatin Analog class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,843 submissions while octreotide has 1,786. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to octreotide changes how the gut absorbs medicine, which can lower the amount of cyclosporine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cyclosporine or octreotide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.