cyclosporine vs eluxadoline
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Side-by-side comparison of cyclosporine and eluxadoline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Table 2: Established and Other Potentially Clinically Relevant Interactions Affecting VIBERZI OATP1B1 Inhibitors Clinical Impact: Increased exposure to eluxadoline when coadministered with cyclosporine [ see Clinical Pharmacology ( 12.3 ) ] Intervention: Administer VIBERZI at a dose of 75 mg twice daily [see Dosage and Administration ( 2 )] and monitor patients for impaired mental or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery and for other eluxadoline-related adverse reactions [see Adverse Reactions ( 6.1 )] ....
Neoral, Sandimmune, Restasis
Viberzi
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Viberzi is a medicine used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults. It helps to reduce diarrhea associated with IBS-D.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Viberzi is used to treat irritable bowel syndrome with diarrhea, also known as IBS-D, in adults. IBS-D can cause stomach pain, bloating, and frequent bowel movements. This medicine can help reduce diarrhea and other symptoms of IBS-D.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
Viberzi works by acting on opioid receptors in your gut. It slows down bowel movements. This helps to reduce diarrhea and abdominal pain.
- • Irritation where the drops are applied (8%)
- • Constipation
- • Nausea
- • Abdominal pain
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
- Abdominal Pain 348
- Diarrhoea 340
- Constipation 281
- Pancreatitis 276
- Nausea 216
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Viberzi can cause serious side effects, including pancreatitis and sphincter of Oddi spasm. These conditions can cause severe abdominal pain, nausea, and vomiting. If you have new or worsening abdominal pain, stop taking Viberzi and get medical help right away. Do not take Viberzi if you do not have a gallbladder.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
It is not known if Viberzi can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Viberzi passes into breast milk. Talk to your doctor about the best way to feed your baby if you take Viberzi.
How to Read This cyclosporine vs eluxadoline Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while eluxadoline sits within the Mu-Opioid Receptor Agonist (IBS-D) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,843 submissions while eluxadoline has 1,461. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to cyclosporine blocks a specific protein that helps remove eluxadoline from your system, which causes eluxadoline levels to rise in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cyclosporine or eluxadoline.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.