cyclobenzaprine vs tramadol
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Side-by-side comparison of cyclobenzaprine and tramadol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Flexeril, Amrix
Ultram, ConZip
Cyclobenzaprine is a muscle relaxant. It helps relieve muscle spasms and pain.
Tramadol extended-release is a strong pain medicine. It is used to treat severe, ongoing pain that needs an opioid medicine when other pain medicines don't work well enough.
This medicine treats muscle spasms caused by painful conditions. It is meant to be used with rest and physical therapy. It should only be used for a short time, usually 2 to 3 weeks.
Tramadol extended-release tablets are used to manage severe, long-lasting pain. This medicine is for pain that requires an opioid and cannot be treated well with other options. It is not for pain that comes and goes.
Cyclobenzaprine works in the brain and spinal cord to relax your muscles. It reduces muscle spasms, which helps to relieve pain and improve movement. It does not directly work on the muscles themselves.
Tramadol works in your brain to change how your body feels pain. It binds to opioid receptors and also affects certain chemicals in the brain. This helps to lessen the pain you feel.
- • Drowsiness
- • Dry mouth
- • Fatigue
- • Headache
- • Dizziness
- • Constipation
- • Feeling sick to your stomach
- • Headache
- • Feeling sleepy
- Pain 4,871
- Fatigue 3,808
- Nausea 3,303
- Headache 3,292
- Chronic Kidney Disease 2,749
- Dependence 7,820
- Overdose 3,855
- Vomiting 3,155
- Pain 2,876
- Nausea 2,712
You should not take this medicine if you are allergic to any of its ingredients. You should not take this medicine if you are taking a monoamine oxidase (MAO) inhibitor or have taken one in the past 14 days. Taking cyclobenzaprine with an MAO inhibitor can cause serious problems, including seizures and death. Also, do not take it if you have heart problems or an overactive thyroid.
Tramadol extended-release tablets can be habit-forming, leading to addiction, abuse, and misuse, which can result in overdose and death. Taking tramadol with other depressants like alcohol or benzodiazepines can cause very serious side effects, including slowed breathing, coma, and death. Even one dose of tramadol can be fatal, especially in children. Using tramadol for a long time during pregnancy can cause withdrawal symptoms in the newborn.
It is not known if cyclobenzaprine can harm an unborn baby. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Tramadol may harm your unborn baby. Breastfeeding is not recommended while taking this medicine, as it can pass into breast milk and harm your baby.
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How to Read This cyclobenzaprine vs tramadol Comparison
cyclobenzaprine is classified in the Muscle Relaxant drug class, while tramadol sits within the Opioid Analgesic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclobenzaprine has 18,023 submissions while tramadol has 20,418. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs increase a brain chemical called serotonin. taking them at the same time can cause serotonin levels to get too high.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cyclobenzaprine or tramadol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.