colestipol vs hydrochlorothiazide/losartan
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of colestipol and hydrochlorothiazide/losartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.5 ) Cholestyramine and colestipol: Reduced absorption of thiazides. Cholestyramine and colestipol resins — Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.
Colestid
Hyzaar
Colestipol is a drug that helps lower cholesterol levels in your blood. It works by binding to bile acids in your intestine, which helps your body get rid of cholesterol.
Hyzaar is a combination medicine that contains losartan and hydrochlorothiazide. It is used to lower high blood pressure.
Colestipol is used along with a healthy diet to lower high cholesterol levels, specifically LDL-C ('bad' cholesterol). It is for people who haven't been able to lower their cholesterol enough with diet alone. Lowering cholesterol can help prevent heart disease and stroke.
Hyzaar is used to treat high blood pressure. Lowering blood pressure reduces your risk of strokes and heart attacks. It is also used to lower the risk of stroke in patients with high blood pressure and an enlarged left ventricle of the heart.
Colestipol is a bile acid sequestrant. It binds to bile acids in your intestines. This helps your body get rid of cholesterol, which lowers the amount of cholesterol in your blood.
Losartan blocks a substance in your body that tightens blood vessels. This helps blood vessels relax, which lowers blood pressure. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
- • Constipation
- • Abdominal discomfort (pain and cramping)
- • Intestinal gas (bloating and flatulence)
- • Indigestion and heartburn
- • Diarrhea and loose stools
- • Dizziness
- • Upper respiratory infection
- • Cough
- • Back pain
- Diarrhoea 358
- Nausea 221
- Fatigue 210
- Headache 136
- Vomiting 125
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
None
If you are pregnant or plan to become pregnant, stop taking Hyzaar and tell your doctor right away. This medicine can harm or kill your unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if colestipol can harm an unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Do not take Hyzaar if you are pregnant. It can cause serious harm to your unborn baby, including kidney problems, lung problems, skeletal problems and even death. If you are breastfeeding, talk to your doctor about whether Hyzaar is right for you.
Also Compare, Nearby Drugs
Compare colestipol with
How to Read This colestipol vs hydrochlorothiazide/losartan Comparison
colestipol is classified in the Bile Acid Sequestrant drug class, while hydrochlorothiazide/losartan sits within the Thiazide Diuretic / ARB Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, colestipol has 1,050 submissions while hydrochlorothiazide/losartan has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this medication can trap the water pill in your digestive system, stopping it from getting into your bloodstream. this means the medicine cannot do its job to lower your blood pressure.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for colestipol or hydrochlorothiazide/losartan.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.