colchicine vs simvastatin
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of colchicine and simvastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with ezetimibe and simvastatin. Intervention: Consider if the benefit of using colchicine concomitantly with ezetimibe and simvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Colcrys, Mitigare
Zocor
Colchicine is a medicine used to prevent or treat gout flares and Familial Mediterranean Fever (FMF). It works by reducing inflammation and pain.
No summary available.
Colchicine is used to prevent and treat gout flares in adults. Gout flares cause sudden, severe pain, redness, and swelling in your joints. Colchicine is also used to treat Familial Mediterranean Fever (FMF) in adults and children ages 4 and older. FMF causes recurring fevers and pain in the abdomen, chest, or joints.
Information not available.
Colchicine reduces inflammation in the body. It does this by blocking certain processes that cause swelling and pain. This helps to relieve gout flares and manage FMF symptoms.
Information not available.
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Vomiting
- • Headache
- • Upper respiratory tract infection
- • Muscle pain
- • Diarrhea
- Diarrhoea 2,660
- Nausea 1,940
- Fatigue 1,747
- Dyspnoea 1,467
- Acute Kidney Injury 1,436
- Fatigue 13,574
- Nausea 12,945
- Dyspnoea 12,431
- Diarrhoea 11,813
- Dizziness 10,971
Taking too much colchicine can be fatal in both adults and children. Keep this medicine out of the reach of children. Colchicine can also cause serious blood problems and muscle weakness. Certain medicines can interact with colchicine and cause life-threatening problems. Talk to your doctor about all the medicines you take.
No specific warnings noted.
Tell your doctor if you are pregnant or plan to become pregnant. Colchicine may harm your unborn baby. It is not known if colchicine passes into breast milk. Talk to your doctor about the risks and benefits of taking colchicine while breastfeeding.
No pregnancy information available.
Also Compare, Nearby Drugs
Compare simvastatin with
How to Read This colchicine vs simvastatin Comparison
colchicine is classified in the Anti-Gout Agent drug class, while simvastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, colchicine has 9,250 submissions while simvastatin has 61,734. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to using these two medicines at the same time can lead to muscle pain and serious muscle damage.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for colchicine or simvastatin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.