codeine vs meperidine
Side-by-side comparison of codeine and meperidine Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Codeine Sulfate
Demerol
This medicine contains acetaminophen and codeine. It is used to treat mild to moderate pain when other pain medicines are not strong enough.
Meperidine is a strong pain medicine. It is used to treat severe, acute pain when other pain medicines are not strong enough.
This medicine is used to manage mild to moderate pain. It is for when an opioid medicine is appropriate. You should only use it if other pain treatments are not working well enough for you.
Meperidine is used to manage acute pain that is severe enough to need an opioid pain medicine. It is for use when other treatments do not work well enough. Meperidine should not be used for chronic, long-lasting pain. Taking meperidine for a long time may increase the risk of seizures.
Codeine works in the brain to change how your body feels and responds to pain. Acetaminophen also helps to relieve pain. Together, they provide pain relief.
Meperidine is an opioid agonist. It works by binding to receptors in the brain and spinal cord. This reduces the feeling of pain.
- • Feeling drowsy
- • Lightheadedness
- • Dizziness
- • Feeling sleepy
- • Shortness of breath
- • Lightheadedness
- • Dizziness
- • Sleepiness
- • Nausea
- • Vomiting
- Allergic reaction to the medicine 806
- Feeling sick to your stomach 487
- Feeling unwell 374
- Medicine not working 370
- Throwing up 364
- Allergic reaction to the drug 3,248
- Drug not working 1,271
- Pain 1,250
- Feeling sick to your stomach 1,133
- Using the drug for a condition it is not approved for 861
This medicine can be habit-forming, leading to addiction, abuse, and misuse, which can result in overdose and death. Serious, life-threatening breathing problems can occur, especially when starting the medicine or after a dose increase. Accidental ingestion, especially by children, can cause a fatal overdose. Do not give this medicine to children under 12 years old, or to children under 18 after tonsil or adenoid removal, due to the risk of life-threatening breathing problems. This medicine can also harm your liver. Taking this medicine with certain other medicines like benzodiazepines or other CNS depressants can cause serious side effects, including death.
Meperidine has a boxed warning. This means it has serious risks. These risks include: Medication errors that can cause overdose, addiction, abuse, and misuse, life-threatening respiratory depression, accidental ingestion (especially by children) can cause a fatal overdose, dangerous effects when taken with benzodiazepines or other CNS depressants, and neonatal opioid withdrawal syndrome. Make sure you read the Medication Guide.
This medicine can cause withdrawal symptoms in newborns if taken during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine passes into breast milk.
Taking meperidine for a long time during pregnancy can cause withdrawal symptoms in the newborn. Meperidine is not recommended during or right before labor because it can cause breathing problems in the baby.
Also Compare — Nearby Drugs
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How to Read This codeine vs meperidine Comparison
codeine is classified in the Opioid Analgesic drug class, while meperidine sits within the Opioid Analgesic class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, codeine has 2,401 submissions while meperidine has 7,763. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between codeine and meperidine — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.