clopidogrel vs darunavir
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Side-by-side comparison of clopidogrel and darunavir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
clopidogrel ↓ clopidogrel active metabolite Co-administration of darunavir/ritonavir and clopidogrel is not recommended due to potential reduction of the antiplatelet activity of clopidogrel.
Plavix
Prezista
Clopidogrel is a drug that helps to prevent blood clots. It is used to lower your risk of heart attack and stroke.
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Clopidogrel is used to prevent heart attack and stroke in adults. It is for people who have had a recent heart attack or stroke. It is also for people with peripheral arterial disease (poor circulation). Clopidogrel can also help people with chest pain or certain heart problems.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Clopidogrel keeps blood platelets from sticking together and forming clots. It blocks a substance that causes platelets to clump. This helps blood flow more freely through your body.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
- • Bleeding
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- Dyspnoea 9,917
- Myocardial Infarction 9,459
- Fatigue 8,479
- Gastrointestinal Haemorrhage 8,202
- Nausea 7,881
- Foetal Exposure During Pregnancy 1,150
- Drug Interaction 981
- Pain 889
- Emotional Distress 812
- Anxiety 811
This drug may not work well for people with certain genes. If you have two copies of a certain gene, clopidogrel may not prevent clots as well. Your doctor may consider a different medicine for you.
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Tell your doctor if you are pregnant or plan to become pregnant. Clopidogrel may increase bleeding during labor and delivery. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
How to Read This clopidogrel vs darunavir Comparison
clopidogrel is classified in the Antiplatelet Agent drug class, while darunavir sits within the HIV Protease Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clopidogrel has 43,938 submissions while darunavir has 4,643. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to darunavir interferes with the body's ability to change clopidogrel into its active form, which means the drug cannot do its job to prevent clots.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for clopidogrel or darunavir.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.