clonidine vs nateglinide
Side-by-side comparison of clonidine and nateglinide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when nateglinide is coadministered with these drugs.
Recommendation: You should check your blood sugar levels more frequently when taking these two medications together.
Catapres
Starlix
Clonidine (Catapres) is a medicine used to treat high blood pressure. It can be used alone or with other blood pressure medicines.
Nateglinide (Starlix) helps control blood sugar in adults with type 2 diabetes. It should be used with diet and exercise.
Clonidine is used to treat high blood pressure. High blood pressure can lead to heart disease, stroke, and kidney problems. This medicine helps to lower your blood pressure to a safer level.
Nateglinide is used to help lower blood sugar in adults who have type 2 diabetes. You should also follow a diet and exercise plan while taking this medicine. Nateglinide should not be used if you have type 1 diabetes or diabetic ketoacidosis.
Clonidine works in the brain to lower blood pressure. It tells your blood vessels to relax and widen. This makes it easier for blood to flow through your body, which lowers blood pressure.
Nateglinide helps your pancreas release insulin after you eat. Insulin helps move sugar from your blood into your cells. This lowers your blood sugar levels after meals.
- • Dry mouth (occurs in about 40 out of 100 people)
- • Drowsiness (occurs in about 33 out of 100 people)
- • Dizziness (occurs in about 16 out of 100 people)
- • Constipation (occurs in about 10 out of 100 people)
- • Feeling sleepy or sedated (occurs in about 10 out of 100 people)
- • Upper respiratory infection
- • Back pain
- • Flu symptoms
- • Dizziness
- • Joint pain
- Pain 3,038
- Tiredness 2,922
- Feeling sick to your stomach 2,918
- Headache 2,799
- High blood pressure 2,597
- High blood sugar 76
- Diarrhea 63
- Difficulty breathing 62
- Tiredness 56
- Feeling sick to your stomach 54
If you suddenly stop taking clonidine, your blood pressure may increase. This can cause serious problems. Talk to your doctor before stopping this medicine.
Nateglinide can cause low blood sugar (hypoglycemia). Take it before meals and skip the dose if you skip the meal to help prevent this. There have been no studies showing that nateglinide lowers your risk of heart or blood vessel problems.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if clonidine will harm your unborn baby. Talk to your doctor if you are breastfeeding.
It is not known if nateglinide can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Nateglinide is not recommended if you are breastfeeding because it may cause low blood sugar in the baby.
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How to Read This clonidine vs nateglinide Comparison
clonidine is classified in the Central Alpha-2 Agonist drug class, while nateglinide sits within the Meglitinide class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clonidine has 14,274 submissions while nateglinide has 311. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to clonidine can hide the normal warning signs of low blood sugar, such as a racing heart or shakiness. this makes it difficult to tell if your blood sugar has dropped to a dangerous level.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between clonidine and nateglinide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.